Cortexin diffusion in human eye sclera

Investigation of the diffusion of cytamines, a typical representative of which is cortexin, is important for evaluating the drug dose, necessary to provide sufficient concentration of the preparation in the inner tissues of the eye. In the present paper, the cortexin diffusion rate in the eye sclera...

Full description

Saved in:
Bibliographic Details
Published in:Quantum electronics (Woodbury, N.Y.) N.Y.), 2011-05, Vol.41 (5), p.407-413
Main Authors: Genina, Elina A, Bashkatov, A N, Tuchin, Valerii V, Ghosn, M G, Larin, Kirill V, Kamenskikh, T G
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
BODY
CRYSTAL DEFECTS
CRYSTAL STRUCTURE
DIAGNOSTIC TECHNIQUES
DIFFUSION
DISPERSIONS
DOSES
DRUGS
EYES
FACE
FLUIDS
HEAD
HOMOGENEOUS MIXTURES
INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
INTERSTITIALS
MIXTURES
OPTICAL EQUIPMENT
ORGANS
POINT DEFECTS
SCATTERING
SENSE ORGANS
SIGNALS
SOLUTIONS
SPECTROSCOPY
TOMOGRAPHY
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Investigation of the diffusion of cytamines, a typical representative of which is cortexin, is important for evaluating the drug dose, necessary to provide sufficient concentration of the preparation in the inner tissues of the eye. In the present paper, the cortexin diffusion rate in the eye sclera is measured using the methods of optical coherence tomography (OCT) and reflectance spectroscopy. The technique for determining the diffusion coefficient is based on the registration of temporal dependence of the eye sclera scattering parameters caused by partial replacement of interstitial fluid with the aqueous cortexin solution, which reduces the level of the OCT signal and decreases the reflectance of the sclera. The values of the cortexin diffusion coefficient obtained using two independent optical methods are in good agreement. (optical technologies in biophysics and medicine)
ISSN:1063-7818
1468-4799
DOI:10.1070/QE2011v041n05ABEH014641