Enhanced Antitumor Effect of Tirapazamine Delivered Intraperitoneally to VX2 Liver Tumor-Bearing Rabbits Subjected to Transarterial Hepatic Embolization

Purpose We evaluated the effects of the combination of Tirapazamine (TPZ), activated preferentially under hypoxic conditions, and gelatin microspheres (GMS) on the tumor growth ratio in rabbits. Methods We assigned 20 liver tumor-bearing Japanese white rabbits to 4 equal groups. Group 1 received 1 m...

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Bibliographic Details
Published in:Cardiovascular and interventional radiology 2011-12, Vol.34 (6), p.1272-1277
Main Authors: Sonoda, Akinaga, Nitta, Norihisa, Ohta, Shinich, Nitta-Seko, Ayumi, Nagatani, Yukihiro, Takahashi, Masashi, Murata, Kiyoshi
Format: Article
Language:English
Subjects:
ANIMALS
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - pharmacology
BLOOD FLOW
BODY
Carcinoma, Hepatocellular - therapy
CARCINOMAS
Cardiology
COLLOIDS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DISPERSIONS
GELATIN
GLANDS
Imaging
Laboratory Investigation
LIVER
Liver Neoplasms, Experimental - therapy
Magnetic Resonance Imaging
MAMMALS
Medicine
Medicine & Public Health
MICROSPHERES
NEOPLASMS
NMR IMAGING
Nuclear Medicine
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PROTEINS
RABBITS
Radiology
RADIOLOGY AND NUCLEAR MEDICINE
Triazines - administration & dosage
Triazines - pharmacology
Ultrasound
VERTEBRATES
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Summary:Purpose We evaluated the effects of the combination of Tirapazamine (TPZ), activated preferentially under hypoxic conditions, and gelatin microspheres (GMS) on the tumor growth ratio in rabbits. Methods We assigned 20 liver tumor-bearing Japanese white rabbits to 4 equal groups. Group 1 received 1 ml of saline intra-arterially (i.a.) and 20 ml of saline intraperitoneally (i.p.; saline group). Group 2 was injected with GMS i.a. and 20 ml saline i.p. (GMS group). Group 3 received 1 ml of saline i.a. and 300 mg/m 2 of TPZ i.p. (TPZ group), and group 4 was treated with GMS i.a. and 300 mg/m 2 of TPZ i.p. (GMS + TPZ group). The infusion of GMS was stopped when the blood flow stagnated. Before and 7 days after treatment, the liver tumor volumes were measured as the total number of pixels on 0.3Tesla (T) magnetic resonance imaging (MRI) scans. Results The tumor growth ratio (mean ± standard deviation) of the saline, GMS, TPZ, and GMS + TPZ groups was 519.15 ± 93.78, 279.24 ± 91.83, 369.78 ± 95.73, and 119.87 ± 17.62, respectively. The difference between the GMS + TPZ group and the other groups was statistically significant ( P  
ISSN:0174-1551
1432-086X
DOI:10.1007/s00270-011-0156-4