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Enhanced Antitumor Effect of Tirapazamine Delivered Intraperitoneally to VX2 Liver Tumor-Bearing Rabbits Subjected to Transarterial Hepatic Embolization
Purpose We evaluated the effects of the combination of Tirapazamine (TPZ), activated preferentially under hypoxic conditions, and gelatin microspheres (GMS) on the tumor growth ratio in rabbits. Methods We assigned 20 liver tumor-bearing Japanese white rabbits to 4 equal groups. Group 1 received 1 m...
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| Published in: | Cardiovascular and interventional radiology 2011-12, Vol.34 (6), p.1272-1277 |
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| container_title | Cardiovascular and interventional radiology |
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| creator | Sonoda, Akinaga Nitta, Norihisa Ohta, Shinich Nitta-Seko, Ayumi Nagatani, Yukihiro Takahashi, Masashi Murata, Kiyoshi |
| description | Purpose
We evaluated the effects of the combination of Tirapazamine (TPZ), activated preferentially under hypoxic conditions, and gelatin microspheres (GMS) on the tumor growth ratio in rabbits.
Methods
We assigned 20 liver tumor-bearing Japanese white rabbits to 4 equal groups. Group 1 received 1 ml of saline intra-arterially (i.a.) and 20 ml of saline intraperitoneally (i.p.; saline group). Group 2 was injected with GMS i.a. and 20 ml saline i.p. (GMS group). Group 3 received 1 ml of saline i.a. and 300 mg/m
2
of TPZ i.p. (TPZ group), and group 4 was treated with GMS i.a. and 300 mg/m
2
of TPZ i.p. (GMS + TPZ group). The infusion of GMS was stopped when the blood flow stagnated. Before and 7 days after treatment, the liver tumor volumes were measured as the total number of pixels on 0.3Tesla (T) magnetic resonance imaging (MRI) scans.
Results
The tumor growth ratio (mean ± standard deviation) of the saline, GMS, TPZ, and GMS + TPZ groups was 519.15 ± 93.78, 279.24 ± 91.83, 369.78 ± 95.73, and 119.87 ± 17.62, respectively. The difference between the GMS + TPZ group and the other groups was statistically significant (
P
|
| doi_str_mv | 10.1007/s00270-011-0156-4 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_21608659</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>908011493</sourcerecordid><originalsourceid>FETCH-LOGICAL-c398t-5ec1f250a1325ccc55a58c6661affe565d3acacb2da81af7c430efabdaa469913</originalsourceid><addsrcrecordid>eNp1kc1u1TAQhS0EopfCA7BBFixYpdhOnJ9lKRda6UqV4IK6syaOQ32V2KntILVPwuMyUUqRKrGwbI2-c8Yzh5DXnJ1wxqoPkTFRsYxxjkeWWfGEbHiRi4zV5dVTsmG8KjIuJT8iL2I8MIRqIZ-TI8GLqqkKuSG_t-4anDYdPXXJpnn0gW773uhEfU_3NsAEdzBaZ-gnM9hfJiB64RLWTbDJOwPDcEuTpz-uBN0tAN0vLtlHA8G6n_QrtK1NkX6b2wPaohzhfQAXIST0gIGemwmS1XQ7tn6wd_j27iV51sMQzav7-5h8_7zdn51nu8svF2enu0znTZ0yaTTvhWTAcyG11lKCrHVZlhxwClnKLgcNuhUd1FiqdJEz00PbARRl0_D8mLxbfX1MVkVtk9HX2juHf1WCl7hK2SD1fqWm4G9mE5MabdRmGMAZP0fVsBpTKJocybePyIOfg8MREKo4dpQlQnyFdPAxBtOrKdgRwq3iTC3RqjVahaZqiVYVqHlzbzy3o-keFH-zRECsQJyWxZvwr_P_Xf8Aek6xIg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>907191356</pqid></control><display><type>article</type><title>Enhanced Antitumor Effect of Tirapazamine Delivered Intraperitoneally to VX2 Liver Tumor-Bearing Rabbits Subjected to Transarterial Hepatic Embolization</title><source>Springer Nature</source><creator>Sonoda, Akinaga ; Nitta, Norihisa ; Ohta, Shinich ; Nitta-Seko, Ayumi ; Nagatani, Yukihiro ; Takahashi, Masashi ; Murata, Kiyoshi</creator><creatorcontrib>Sonoda, Akinaga ; Nitta, Norihisa ; Ohta, Shinich ; Nitta-Seko, Ayumi ; Nagatani, Yukihiro ; Takahashi, Masashi ; Murata, Kiyoshi</creatorcontrib><description>Purpose
We evaluated the effects of the combination of Tirapazamine (TPZ), activated preferentially under hypoxic conditions, and gelatin microspheres (GMS) on the tumor growth ratio in rabbits.
Methods
We assigned 20 liver tumor-bearing Japanese white rabbits to 4 equal groups. Group 1 received 1 ml of saline intra-arterially (i.a.) and 20 ml of saline intraperitoneally (i.p.; saline group). Group 2 was injected with GMS i.a. and 20 ml saline i.p. (GMS group). Group 3 received 1 ml of saline i.a. and 300 mg/m
2
of TPZ i.p. (TPZ group), and group 4 was treated with GMS i.a. and 300 mg/m
2
of TPZ i.p. (GMS + TPZ group). The infusion of GMS was stopped when the blood flow stagnated. Before and 7 days after treatment, the liver tumor volumes were measured as the total number of pixels on 0.3Tesla (T) magnetic resonance imaging (MRI) scans.
Results
The tumor growth ratio (mean ± standard deviation) of the saline, GMS, TPZ, and GMS + TPZ groups was 519.15 ± 93.78, 279.24 ± 91.83, 369.78 ± 95.73, and 119.87 ± 17.62, respectively. The difference between the GMS + TPZ group and the other groups was statistically significant (
P
< 0.05).
Conclusions
Our results show that the combination of TPZ i.p. and GMS i.a. enhanced the antitumor effect of TPZ. This procedure may represent a new alternative treatment for patients with hepatic cell carcinoma.</description><identifier>ISSN: 0174-1551</identifier><identifier>EISSN: 1432-086X</identifier><identifier>DOI: 10.1007/s00270-011-0156-4</identifier><identifier>PMID: 21479745</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>ANIMALS ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - pharmacology ; BLOOD FLOW ; BODY ; Carcinoma, Hepatocellular - therapy ; CARCINOMAS ; Cardiology ; COLLOIDS ; DIAGNOSTIC TECHNIQUES ; DIGESTIVE SYSTEM ; DISEASES ; DISPERSIONS ; GELATIN ; GLANDS ; Imaging ; Laboratory Investigation ; LIVER ; Liver Neoplasms, Experimental - therapy ; Magnetic Resonance Imaging ; MAMMALS ; Medicine ; Medicine & Public Health ; MICROSPHERES ; NEOPLASMS ; NMR IMAGING ; Nuclear Medicine ; ORGANIC COMPOUNDS ; ORGANS ; PATIENTS ; PROTEINS ; RABBITS ; Radiology ; RADIOLOGY AND NUCLEAR MEDICINE ; Triazines - administration & dosage ; Triazines - pharmacology ; Ultrasound ; VERTEBRATES</subject><ispartof>Cardiovascular and interventional radiology, 2011-12, Vol.34 (6), p.1272-1277</ispartof><rights>Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-5ec1f250a1325ccc55a58c6661affe565d3acacb2da81af7c430efabdaa469913</citedby><cites>FETCH-LOGICAL-c398t-5ec1f250a1325ccc55a58c6661affe565d3acacb2da81af7c430efabdaa469913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21479745$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/21608659$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Sonoda, Akinaga</creatorcontrib><creatorcontrib>Nitta, Norihisa</creatorcontrib><creatorcontrib>Ohta, Shinich</creatorcontrib><creatorcontrib>Nitta-Seko, Ayumi</creatorcontrib><creatorcontrib>Nagatani, Yukihiro</creatorcontrib><creatorcontrib>Takahashi, Masashi</creatorcontrib><creatorcontrib>Murata, Kiyoshi</creatorcontrib><title>Enhanced Antitumor Effect of Tirapazamine Delivered Intraperitoneally to VX2 Liver Tumor-Bearing Rabbits Subjected to Transarterial Hepatic Embolization</title><title>Cardiovascular and interventional radiology</title><addtitle>Cardiovasc Intervent Radiol</addtitle><addtitle>Cardiovasc Intervent Radiol</addtitle><description>Purpose
We evaluated the effects of the combination of Tirapazamine (TPZ), activated preferentially under hypoxic conditions, and gelatin microspheres (GMS) on the tumor growth ratio in rabbits.
Methods
We assigned 20 liver tumor-bearing Japanese white rabbits to 4 equal groups. Group 1 received 1 ml of saline intra-arterially (i.a.) and 20 ml of saline intraperitoneally (i.p.; saline group). Group 2 was injected with GMS i.a. and 20 ml saline i.p. (GMS group). Group 3 received 1 ml of saline i.a. and 300 mg/m
2
of TPZ i.p. (TPZ group), and group 4 was treated with GMS i.a. and 300 mg/m
2
of TPZ i.p. (GMS + TPZ group). The infusion of GMS was stopped when the blood flow stagnated. Before and 7 days after treatment, the liver tumor volumes were measured as the total number of pixels on 0.3Tesla (T) magnetic resonance imaging (MRI) scans.
Results
The tumor growth ratio (mean ± standard deviation) of the saline, GMS, TPZ, and GMS + TPZ groups was 519.15 ± 93.78, 279.24 ± 91.83, 369.78 ± 95.73, and 119.87 ± 17.62, respectively. The difference between the GMS + TPZ group and the other groups was statistically significant (
P
< 0.05).
Conclusions
Our results show that the combination of TPZ i.p. and GMS i.a. enhanced the antitumor effect of TPZ. This procedure may represent a new alternative treatment for patients with hepatic cell carcinoma.</description><subject>ANIMALS</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>BLOOD FLOW</subject><subject>BODY</subject><subject>Carcinoma, Hepatocellular - therapy</subject><subject>CARCINOMAS</subject><subject>Cardiology</subject><subject>COLLOIDS</subject><subject>DIAGNOSTIC TECHNIQUES</subject><subject>DIGESTIVE SYSTEM</subject><subject>DISEASES</subject><subject>DISPERSIONS</subject><subject>GELATIN</subject><subject>GLANDS</subject><subject>Imaging</subject><subject>Laboratory Investigation</subject><subject>LIVER</subject><subject>Liver Neoplasms, Experimental - therapy</subject><subject>Magnetic Resonance Imaging</subject><subject>MAMMALS</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>MICROSPHERES</subject><subject>NEOPLASMS</subject><subject>NMR IMAGING</subject><subject>Nuclear Medicine</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANS</subject><subject>PATIENTS</subject><subject>PROTEINS</subject><subject>RABBITS</subject><subject>Radiology</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Triazines - administration & dosage</subject><subject>Triazines - pharmacology</subject><subject>Ultrasound</subject><subject>VERTEBRATES</subject><issn>0174-1551</issn><issn>1432-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp1kc1u1TAQhS0EopfCA7BBFixYpdhOnJ9lKRda6UqV4IK6syaOQ32V2KntILVPwuMyUUqRKrGwbI2-c8Yzh5DXnJ1wxqoPkTFRsYxxjkeWWfGEbHiRi4zV5dVTsmG8KjIuJT8iL2I8MIRqIZ-TI8GLqqkKuSG_t-4anDYdPXXJpnn0gW773uhEfU_3NsAEdzBaZ-gnM9hfJiB64RLWTbDJOwPDcEuTpz-uBN0tAN0vLtlHA8G6n_QrtK1NkX6b2wPaohzhfQAXIST0gIGemwmS1XQ7tn6wd_j27iV51sMQzav7-5h8_7zdn51nu8svF2enu0znTZ0yaTTvhWTAcyG11lKCrHVZlhxwClnKLgcNuhUd1FiqdJEz00PbARRl0_D8mLxbfX1MVkVtk9HX2juHf1WCl7hK2SD1fqWm4G9mE5MabdRmGMAZP0fVsBpTKJocybePyIOfg8MREKo4dpQlQnyFdPAxBtOrKdgRwq3iTC3RqjVahaZqiVYVqHlzbzy3o-keFH-zRECsQJyWxZvwr_P_Xf8Aek6xIg</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Sonoda, Akinaga</creator><creator>Nitta, Norihisa</creator><creator>Ohta, Shinich</creator><creator>Nitta-Seko, Ayumi</creator><creator>Nagatani, Yukihiro</creator><creator>Takahashi, Masashi</creator><creator>Murata, Kiyoshi</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>20111201</creationdate><title>Enhanced Antitumor Effect of Tirapazamine Delivered Intraperitoneally to VX2 Liver Tumor-Bearing Rabbits Subjected to Transarterial Hepatic Embolization</title><author>Sonoda, Akinaga ; Nitta, Norihisa ; Ohta, Shinich ; Nitta-Seko, Ayumi ; Nagatani, Yukihiro ; Takahashi, Masashi ; Murata, Kiyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-5ec1f250a1325ccc55a58c6661affe565d3acacb2da81af7c430efabdaa469913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>ANIMALS</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>BLOOD FLOW</topic><topic>BODY</topic><topic>Carcinoma, Hepatocellular - therapy</topic><topic>CARCINOMAS</topic><topic>Cardiology</topic><topic>COLLOIDS</topic><topic>DIAGNOSTIC TECHNIQUES</topic><topic>DIGESTIVE SYSTEM</topic><topic>DISEASES</topic><topic>DISPERSIONS</topic><topic>GELATIN</topic><topic>GLANDS</topic><topic>Imaging</topic><topic>Laboratory Investigation</topic><topic>LIVER</topic><topic>Liver Neoplasms, Experimental - therapy</topic><topic>Magnetic Resonance Imaging</topic><topic>MAMMALS</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>MICROSPHERES</topic><topic>NEOPLASMS</topic><topic>NMR IMAGING</topic><topic>Nuclear Medicine</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANS</topic><topic>PATIENTS</topic><topic>PROTEINS</topic><topic>RABBITS</topic><topic>Radiology</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Triazines - administration & dosage</topic><topic>Triazines - pharmacology</topic><topic>Ultrasound</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sonoda, Akinaga</creatorcontrib><creatorcontrib>Nitta, Norihisa</creatorcontrib><creatorcontrib>Ohta, Shinich</creatorcontrib><creatorcontrib>Nitta-Seko, Ayumi</creatorcontrib><creatorcontrib>Nagatani, Yukihiro</creatorcontrib><creatorcontrib>Takahashi, Masashi</creatorcontrib><creatorcontrib>Murata, Kiyoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Cardiovascular and interventional radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sonoda, Akinaga</au><au>Nitta, Norihisa</au><au>Ohta, Shinich</au><au>Nitta-Seko, Ayumi</au><au>Nagatani, Yukihiro</au><au>Takahashi, Masashi</au><au>Murata, Kiyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced Antitumor Effect of Tirapazamine Delivered Intraperitoneally to VX2 Liver Tumor-Bearing Rabbits Subjected to Transarterial Hepatic Embolization</atitle><jtitle>Cardiovascular and interventional radiology</jtitle><stitle>Cardiovasc Intervent Radiol</stitle><addtitle>Cardiovasc Intervent Radiol</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>34</volume><issue>6</issue><spage>1272</spage><epage>1277</epage><pages>1272-1277</pages><issn>0174-1551</issn><eissn>1432-086X</eissn><abstract>Purpose
We evaluated the effects of the combination of Tirapazamine (TPZ), activated preferentially under hypoxic conditions, and gelatin microspheres (GMS) on the tumor growth ratio in rabbits.
Methods
We assigned 20 liver tumor-bearing Japanese white rabbits to 4 equal groups. Group 1 received 1 ml of saline intra-arterially (i.a.) and 20 ml of saline intraperitoneally (i.p.; saline group). Group 2 was injected with GMS i.a. and 20 ml saline i.p. (GMS group). Group 3 received 1 ml of saline i.a. and 300 mg/m
2
of TPZ i.p. (TPZ group), and group 4 was treated with GMS i.a. and 300 mg/m
2
of TPZ i.p. (GMS + TPZ group). The infusion of GMS was stopped when the blood flow stagnated. Before and 7 days after treatment, the liver tumor volumes were measured as the total number of pixels on 0.3Tesla (T) magnetic resonance imaging (MRI) scans.
Results
The tumor growth ratio (mean ± standard deviation) of the saline, GMS, TPZ, and GMS + TPZ groups was 519.15 ± 93.78, 279.24 ± 91.83, 369.78 ± 95.73, and 119.87 ± 17.62, respectively. The difference between the GMS + TPZ group and the other groups was statistically significant (
P
< 0.05).
Conclusions
Our results show that the combination of TPZ i.p. and GMS i.a. enhanced the antitumor effect of TPZ. This procedure may represent a new alternative treatment for patients with hepatic cell carcinoma.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>21479745</pmid><doi>10.1007/s00270-011-0156-4</doi><tpages>6</tpages></addata></record> |
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| source | Springer Nature |
| subjects | ANIMALS Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology BLOOD FLOW BODY Carcinoma, Hepatocellular - therapy CARCINOMAS Cardiology COLLOIDS DIAGNOSTIC TECHNIQUES DIGESTIVE SYSTEM DISEASES DISPERSIONS GELATIN GLANDS Imaging Laboratory Investigation LIVER Liver Neoplasms, Experimental - therapy Magnetic Resonance Imaging MAMMALS Medicine Medicine & Public Health MICROSPHERES NEOPLASMS NMR IMAGING Nuclear Medicine ORGANIC COMPOUNDS ORGANS PATIENTS PROTEINS RABBITS Radiology RADIOLOGY AND NUCLEAR MEDICINE Triazines - administration & dosage Triazines - pharmacology Ultrasound VERTEBRATES |
| title | Enhanced Antitumor Effect of Tirapazamine Delivered Intraperitoneally to VX2 Liver Tumor-Bearing Rabbits Subjected to Transarterial Hepatic Embolization |
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