Histological evaluation of high-intensity focused ultrasound with lower-intensity focused ultrasound pre-exposure on the treatment of rabbit VX2 liver tumors

This study was to evaluate the effect of pre-exposure lower-intensity focused ultrasound(US), or LIFU, in high-intensity focused ultrasound(HIFU) ablation of rabbit VX2 liver tumors . Liver VX2 tumor models were established in 30 rabbits, which were divided randomly into two groups. The liver tumors...

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Bibliographic Details
Main Authors: Zou Hairong, Zou Jianzhong, Wang Yan, Ou Xia
Format: Conference Proceeding
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
ABLATION
BIOLOGICAL EFFECTS
EVALUATION
LIVER
NEOPLASMS
OPTICAL MICROSCOPY
RABBITS
THERAPY
TRANSMISSION ELECTRON MICROSCOPY
TUMOR CELLS
ULTRASONOGRAPHY
VISIBLE RADIATION
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Summary:This study was to evaluate the effect of pre-exposure lower-intensity focused ultrasound(US), or LIFU, in high-intensity focused ultrasound(HIFU) ablation of rabbit VX2 liver tumors . Liver VX2 tumor models were established in 30 rabbits, which were divided randomly into two groups. The liver tumors of rabbits in Group A underwent single HIFU ablation; those in Group B were given LIFU exposure before HIFU treatment. Five rabbits from each of the two groups were sacrificed at 0 hours, 3 days, and 7 days after HIFU ablation. Tissue samples that included targeted and short-range sounding (s-RS, within 5 mm of the targeted) and far-range sounding (f-RS, more than 5 mm of the targeted) tissues were observed using light microscope and transmission electron microscopy. The histological examination indicated that not only the targeted tumor cells became irreversible damage, but also the short-range sounding tumors were severely damaged by the HIFU with LIFU pre-exposure in group B. It is concluded that LIFU pre-exposure can enhance the effects of HIFU ablation on the destruction of cell ultrastructures and can enlarge the region of HIFU ablation.
ISSN:0094-243X
1551-7616
DOI:10.1063/1.4757383