Nephrotoxicity of uranium in drinking water from private drilled wells

To investigate the association between uranium in drinking water from drilled wells and aspects of kidney function measured by sensitive urine tests. Three hundred and one of 398 eligible subjects (75.6%) aged 18–74 years with daily drinking water supplies from private drilled wells located in urani...

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Bibliographic Details
Published in:Environmental research 2009-05, Vol.109 (4), p.486-494
Main Authors: Seldén, Anders I., Lundholm, Cecilia, Edlund, Bror, Högdahl, Camilla, Ek, Britt-Marie, Bergström, Bernt E., Ohlson, Carl-Göran
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
Adolescent
Adult
Aged
Air. Soil. Water. Waste. Feeding
ALBUMINS
Biological and medical sciences
Biomarkers - urine
Case-Control Studies
DIABETES MELLITUS
Drinking
DRINKING WATER
Environment. Living conditions
Environmental epidemiology
Environmental Exposure
EPIDEMIOLOGY
Female
Glomerular Filtration Rate - drug effects
Glomerular Filtration Rate - physiology
Humans
IMMUNOGLOBULINS
Kidney - drug effects
Kidney - physiology
Kidney Function Tests
KIDNEYS
Male
Medical sciences
Middle Aged
Public Health
Public health. Hygiene
Public health. Hygiene-occupational medicine
Sweden
URANIUM
Uranium - analysis
Uranium - toxicity
Uranium - urine
URINE
Water Pollutants, Radioactive - analysis
Water Pollutants, Radioactive - toxicity
Water Pollutants, Radioactive - urine
Young Adult
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Summary:To investigate the association between uranium in drinking water from drilled wells and aspects of kidney function measured by sensitive urine tests. Three hundred and one of 398 eligible subjects (75.6%) aged 18–74 years with daily drinking water supplies from private drilled wells located in uranium-rich bedrock (exposed group) volunteered to participate along with 153 of 271 local controls (56.4%) who used municipal water. Participants responded to a questionnaire on their water consumption and general health, and provided a morning urine sample and drinking water for analysis. The uranium content of well water samples (n=153) varied considerably (range 100μg/l), while uranium levels in all samples of municipal water (n=14) were below the limit of quantification (0.2μg/l). Urinary levels of uranium were more than eight times higher in exposed subjects than in controls (geometric means 38 and 4.3ng/l, respectively; p
ISSN:0013-9351
1096-0953
DOI:10.1016/j.envres.2009.02.002