Gastric acid reduction leads to an alteration in lower intestinal microflora

To clarify the alterations in lower intestinal microflora induced by gastric acid reduction, the dynamics of 12 major genera or groups of bacteria comprising the microflora in feces and colonic contents were examined by quantitative real-time PCR in proton pump inhibitor-treated rats and in asymptom...

Full description

Saved in:
Bibliographic Details
Published in:Biochemical and biophysical research communications 2009-04, Vol.381 (4), p.666-670
Main Authors: Kanno, Takayuki, Matsuki, Takahiro, Oka, Masashi, Utsunomiya, Hirotoshi, Inada, Kenichi, Magari, Hirohito, Inoue, Izumi, Maekita, Takao, Ueda, Kazuki, Enomoto, Shotaro, Iguchi, Mikitaka, Yanaoka, Kimihiko, Tamai, Hideyuki, Akimoto, Shigeru, Nomoto, Koji, Tanaka, Ryuichiro, Ichinose, Masao
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
Adult
Animals
BACTERIA
Bacteria - classification
Bacteria - isolation & purification
Bacterial overgrowth
Bifidobacterium
Chronic atrophic gastritis
Colon - microbiology
DIFFUSION BARRIERS
FECES
Female
GASTRIC ACID
Gastric Acid - secretion
Gastric acid barrier
Humans
Hypochlorhydria
Intestinal microflora
Lactobacillus
Male
Middle Aged
POLYMERASE CHAIN REACTION
Proton pump inhibitor
PUMPS
RATS
Rats, Wistar
REDUCTION
Veillonella
VENTILATION BARRIERS
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To clarify the alterations in lower intestinal microflora induced by gastric acid reduction, the dynamics of 12 major genera or groups of bacteria comprising the microflora in feces and colonic contents were examined by quantitative real-time PCR in proton pump inhibitor-treated rats and in asymptomatic human subjects with hypochlorhydria. In both rat and human experiments, most genera or groups of intestinal microflora (facultative and obligate anaerobes) proliferated by gastric acid reduction, and marked and significant increases in the Lactobacilli group and Veillonella, oropharyngeal bacteria, were observed. In rats, potent gastric acid inhibition led to a marked and significant increase of intestinal bacteria, including the Bacteroidesfragilis group, while Bifidobacterium, a beneficial bacterial species, remained at a constant level. These results strongly indicate that the gastric acid barrier not only controls the colonization and growth of oropharyngeal bacteria, but also regulates the population and composition of lower intestinal microflora.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2009.02.109