Survival analysis of colorectal cancer patients with tumor recurrence using global score test methodology

Colorectal cancer is the third and the second most common cancer worldwide in men and women respectively, and the second in Malaysia for both genders. Surgery, chemotherapy and radiotherapy are among the options available for treatment of patients with colorectal cancer. In clinical trials, the main...

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Bibliographic Details
Main Authors: Zain Zakiyah, Aziz Nazrina, Yuhaniz, Ahmad, Zairul, Azwan, Raduan Farhana, Ismail, Sagap
Format: Conference Proceeding
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
Cancer
Cancer therapies
CHEMOTHERAPY
Colorectal cancer
COMPARATIVE EVALUATIONS
CONTROL
DEATH
DIAGNOSIS
Ethnic factors
HOSPITALS
MALAYSIA
Medical research
MEN
NEOPLASMS
PATIENTS
Radiation therapy
RADIOLOGY AND NUCLEAR MEDICINE
RADIOTHERAPY
Statistical tests
STATISTICS
SURGERY
Survival
Survival analysis
Tumors
WOMEN
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Summary:Colorectal cancer is the third and the second most common cancer worldwide in men and women respectively, and the second in Malaysia for both genders. Surgery, chemotherapy and radiotherapy are among the options available for treatment of patients with colorectal cancer. In clinical trials, the main purpose is often to compare efficacy between experimental and control treatments. Treatment comparisons often involve several responses or endpoints, and this situation complicates the analysis. In the case of colorectal cancer, sets of responses concerned with survival times include: times from tumor removal until the first, the second and the third tumor recurrences, and time to death. For a patient, the time to recurrence is correlated to the overall survival. In this study, global score test methodology is used in combining the univariate score statistics for comparing treatments with respect to each survival endpoint into a single statistic. The data of tumor recurrence and overall survival of colorectal cancer patients are taken from a Malaysian hospital. The results are found to be similar to those computed using the established Wei, Lin and Weissfeld method. Key factors such as ethnic, gender, age and stage at diagnose are also reported.
ISSN:0094-243X
1551-7616
DOI:10.1063/1.4903697