Cycling with BRCA2 from DNA repair to mitosis

Genetic integrity in proliferating cells is guaranteed by the harmony of DNA replication, appropriate DNA repair, and segregation of the duplicated genome. Breast cancer susceptibility gene BRCA2 is a unique tumor suppressor that is involved in all three processes. Hence, it is critical in genome ma...

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Bibliographic Details
Published in:Experimental cell research 2014-11, Vol.329 (1), p.78-84
Main Author: Lee, Hyunsook
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
Animals
BRCA2
BRCA2 Protein - genetics
Breast cancer
CELL CYCLE
Cell Cycle - genetics
Cell division
Cytokinesis
DNA REPAIR
DNA Repair - genetics
DNA REPLICATION
GENES
Genomics
HDR (homology-directed recombination)
HOMEOSTASIS
Humans
Kinases
MAMMARY GLANDS
MITOSIS
Mitosis - genetics
NEOPLASMS
PHOSPHOTRANSFERASES
Replication fork
Spindle assembly checkpoint (SAC)
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Summary:Genetic integrity in proliferating cells is guaranteed by the harmony of DNA replication, appropriate DNA repair, and segregation of the duplicated genome. Breast cancer susceptibility gene BRCA2 is a unique tumor suppressor that is involved in all three processes. Hence, it is critical in genome maintenance. The functions of BRCA2 in DNA repair and homology-directed recombination (HDR) have been reviewed numerous times. Here, I will briefly go through the functions of BRCA2 in HDR and focus on the emerging roles of BRCA2 in telomere homeostasis and mitosis, then discuss how BRCA2 exerts distinct functions in a cell-cycle specific manner in the maintenance of genomic integrity. •BRCA2 is a multifaceted tumor suppressor and is crucial in genetic integrity.•BRCA2 exerts distinct functions in cell cycle-specific manner.•Mitotic kinases regulate diverse functions of BRCA2 in mitosis and cytokinesis.
ISSN:0014-4827
1090-2422
DOI:10.1016/j.yexcr.2014.10.008