The adverse effects of aldrin and dieldrin on both myometrial contractions and the secretory functions of bovine ovaries and uterus in vitro

Aldrin and dieldrin are chloroorganic insecticides which are recognised as endocrine disruptors. The aim of the study was to investigate their effect on the secretory functions of the uterus and ovary and on myometrial contractions. Myometrial strips and uterine and ovarian cells from nonpregnant co...

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Bibliographic Details
Published in:Toxicology and applied pharmacology 2015-05, Vol.285 (1), p.23-31
Main Authors: Wrobel, Michał H., Grzeszczyk, Marlena, Mlynarczuk, Jaroslaw, Kotwica, Jan
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
ACTINOMYCIN
ALDRIN
Aldrin - toxicity
Animals
ARACHIDONIC ACID
Cattle
Cells, Cultured
Chloroorganic insecticides
CONTRACTION
Contractions
Cow
COWS
DDT
DIELDRIN
Dieldrin - toxicity
Dinoprost - secretion
Dinoprostone - secretion
Dose-Response Relationship, Drug
Endocrine Disruptors - toxicity
Estradiol - secretion
Female
Gene Expression Regulation, Enzymologic - drug effects
Granulosa Cells - drug effects
Granulosa Cells - secretion
IN VITRO
Insecticides - toxicity
Luteal Cells - drug effects
Luteal Cells - secretion
OVARIES
Ovary
Ovary - drug effects
Ovary - secretion
OXYTOCIN
Oxytocin - secretion
PARTURITION
PROGESTERONE
Progesterone - secretion
PROSTAGLANDINS
SALTS
SECRETION
TESTOSTERONE
Testosterone - secretion
TETRAZOLIUM
Time Factors
Tissue Culture Techniques
Uterine Contraction - drug effects
UTERUS
Uterus - drug effects
Uterus - secretion
VIABILITY
XENOBIOTICS
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Summary:Aldrin and dieldrin are chloroorganic insecticides which are recognised as endocrine disruptors. The aim of the study was to investigate their effect on the secretory functions of the uterus and ovary and on myometrial contractions. Myometrial strips and uterine and ovarian cells from nonpregnant cows were incubated with the xenobiotics (0.1, 1 or 10ng/ml) for 24 or 72h. Next, their effect on viability of myometrial, endometrial, granulosa and luteal cells, myometrial strip contractions, the synthesis and secretion of prostaglandins (PGs: PGF2α and PGE2) from uterine cells, the secretion of oestradiol (E2), testosterone (T) and oxytocin (OT) from granulosa cells and the secretion of progesterone (P4) and OT from luteal cells were determined. Neither of the xenobiotics (10ng/ml) affected (P>0.05) the viability of the ovarian and uterine cells, while both (0.1–10ng/ml) decreased (P0.05) the synthesis and the secretion of PGs from the myometrial cells. Although they also did not impair the secretion of the PGs from the endometrial cells, they abolished (P
ISSN:0041-008X
1096-0333
DOI:10.1016/j.taap.2015.03.005