Loading…

Image-Guided Cryoablation of the Spine in a Swine Model: Clinical, Radiological, and Pathological Findings with Light and Electron Microscopy

Purpose This study was designed to present the feasibility of an in vivo image-guided percutaneous cryoablation of the porcine vertebral body. Methods The institutional animal care committee approved this study. Cone-beam computed tomography (CBCT)-guided vertebral cryoablations ( n  = 22) were perf...

Full description

Saved in:
Bibliographic Details
Published in:Cardiovascular and interventional radiology 2015-10, Vol.38 (5), p.1261-1270
Main Authors: de Freitas, Ricardo Miguel Costa, Andrade, Celi Santos, Caldas, José Guilherme Mendes Pereira, Tsunemi, Miriam Harumi, Ferreira, Lorraine Braga, Arana-Chavez, Victor Elias, Cury, Patrícia Maluf
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose This study was designed to present the feasibility of an in vivo image-guided percutaneous cryoablation of the porcine vertebral body. Methods The institutional animal care committee approved this study. Cone-beam computed tomography (CBCT)-guided vertebral cryoablations ( n  = 22) were performed in eight pigs with short, 2-min, single or double-freezing protocols. Protective measures to nerves included dioxide carbon (CO 2 ) epidural injections and spinal canal temperature monitoring. Clinical, radiological, and pathological data with light ( n  = 20) or transmission electron ( n  = 2) microscopic analyses were evaluated after 6 days of clinical follow-up and euthanasia. Results CBCT/fluoroscopic-guided transpedicular vertebral body cryoprobe positioning and CO 2 epidural injection were successful in all procedures. No major complications were observed in seven animals (87.5 %, n  = 8). A minor complication was observed in one pig (12.5 %, n  = 1). Logistic regression model analysis showed the cryoprobe-spinal canal (Cp-Sc) distance as the most efficient parameter to categorize spinal canal temperatures lower than 19 °C ( p  
ISSN:0174-1551
1432-086X
DOI:10.1007/s00270-014-1043-6