Impact of plasma jet vacuum ultraviolet radiation on reactive oxygen species generation in bio-relevant liquids

Plasma medicine utilizes the combined interaction of plasma produced reactive components. These are reactive atoms, molecules, ions, metastable species, and radiation. Here, ultraviolet (UV, 100–400 nm) and, in particular, vacuum ultraviolet (VUV, 10–200 nm) radiation generated by an atmospheric pre...

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Bibliographic Details
Published in:Physics of plasmas 2015-12, Vol.22 (12)
Main Authors: Jablonowski, H., Bussiahn, R., Hammer, M. U., Weltmann, K.-D., von Woedtke, Th, Reuter, S.
Format: Article
Language:English
Subjects:
70 PLASMA PHYSICS AND FUSION TECHNOLOGY
ANIONS
ARGON
Argon plasma
ATMOSPHERIC PRESSURE
CELL CULTURES
Distilled water
Electron paramagnetic resonance
ELECTRON SPIN RESONANCE
Emission analysis
ENERGY ABSORPTION
FAR ULTRAVIOLET RADIATION
HYDROGEN PEROXIDE
HYDROXYL RADICALS
INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY
MEDICINE
OXYGEN
Photoelectric emission
PHOTOEMISSION
Plasma
PLASMA JETS
Plasma physics
Sodium chloride
SODIUM CHLORIDES
SPECTROSCOPY
Ultraviolet radiation
WATER
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Summary:Plasma medicine utilizes the combined interaction of plasma produced reactive components. These are reactive atoms, molecules, ions, metastable species, and radiation. Here, ultraviolet (UV, 100–400 nm) and, in particular, vacuum ultraviolet (VUV, 10–200 nm) radiation generated by an atmospheric pressure argon plasma jet were investigated regarding plasma emission, absorption in a humidified atmosphere and in solutions relevant for plasma medicine. The energy absorption was obtained for simple solutions like distilled water (dH2O) or ultrapure water and sodium chloride (NaCl) solution as well as for more complex ones, for example, Rosewell Park Memorial Institute (RPMI 1640) cell culture media. As moderate stable reactive oxygen species, hydrogen peroxide (H2O2) was studied. Highly reactive oxygen radicals, namely, superoxide anion (O2•−) and hydroxyl radicals (•OH), were investigated by the use of electron paramagnetic resonance spectroscopy. All species amounts were detected for three different treatment cases: Plasma jet generated VUV and UV radiation, plasma jet generated UV radiation without VUV part, and complete plasma jet including all reactive components additionally to VUV and UV radiation. It was found that a considerable amount of radicals are generated by the plasma generated photoemission. From the experiments, estimation on the low hazard potential of plasma generated VUV radiation is discussed.
ISSN:1070-664X
1089-7674
DOI:10.1063/1.4934989