Loading…
MO‐FG‐303‐08: PET‐Detectable Bimetallic (Zn@Au) Nanoparticles for Radiotherapy and Molecular Imaging Applications
Purpose: A technical challenge in clinical translation of GNP‐mediated radiotherapy is lack of in‐vivo imaging tools for monitoring biodistribution of GNPs. While several modalities (x‐ray fluorescence, photoacoustic, etc.) are investigated, we propose a potentially more effective technique based on...
Saved in:
Published in: | Medical physics (Lancaster) 2015-06, Vol.42 (6Part29), p.3568-3568 |
---|---|
Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Purpose:
A technical challenge in clinical translation of GNP‐mediated radiotherapy is lack of in‐vivo imaging tools for monitoring biodistribution of GNPs. While several modalities (x‐ray fluorescence, photoacoustic, etc.) are investigated, we propose a potentially more effective technique based on PET imaging. We developed Zn@Au NPs whose Zn core acts as positron emitters when activated by protons, while the Au shell plays the original role for GNP‐mediated radiosensitization.
Methods:
Spherical Zn NPs (∼7nm diameter) were synthesized and then coated with ∼7nm thick Au layer to make Zn@Au NPs (∼20nm diameter). A water slurry containing 29mg of Zn@Au NPs was deposited ( |
---|---|
ISSN: | 0094-2405 2473-4209 |
DOI: | 10.1118/1.4925421 |