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MO‐FG‐303‐08: PET‐Detectable Bimetallic (Zn@Au) Nanoparticles for Radiotherapy and Molecular Imaging Applications

Purpose: A technical challenge in clinical translation of GNP‐mediated radiotherapy is lack of in‐vivo imaging tools for monitoring biodistribution of GNPs. While several modalities (x‐ray fluorescence, photoacoustic, etc.) are investigated, we propose a potentially more effective technique based on...

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Bibliographic Details
Published in:Medical physics (Lancaster) 2015-06, Vol.42 (6Part29), p.3568-3568
Main Authors: Cho, J, Wang, M, Gonzalez‐Lepera, C, Zubarev, E, Cho, S
Format: Article
Language:English
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Summary:Purpose: A technical challenge in clinical translation of GNP‐mediated radiotherapy is lack of in‐vivo imaging tools for monitoring biodistribution of GNPs. While several modalities (x‐ray fluorescence, photoacoustic, etc.) are investigated, we propose a potentially more effective technique based on PET imaging. We developed Zn@Au NPs whose Zn core acts as positron emitters when activated by protons, while the Au shell plays the original role for GNP‐mediated radiosensitization. Methods: Spherical Zn NPs (∼7nm diameter) were synthesized and then coated with ∼7nm thick Au layer to make Zn@Au NPs (∼20nm diameter). A water slurry containing 29mg of Zn@Au NPs was deposited (
ISSN:0094-2405
2473-4209
DOI:10.1118/1.4925421