TU‐G‐BRA‐04: Changes in Regional Lung Function Measured by 4D‐CT Ventilation Imaging for Thoracic Radiotherapy

Purpose: To test the hypothesis: 4D‐CT ventilation imaging can show the known effects of radiotherapy on lung function: (1) radiation‐induced ventilation reductions, and (2) ventilation increases caused by tumor regression. Methods: Repeat 4D‐CT scans (pre‐, mid‐ and/or post‐treatment) were acquired...

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Bibliographic Details
Published in:Medical physics (Lancaster) 2015-06, Vol.42 (6Part35), p.3630-3631
Main Authors: Nakajima, Y, Kadoya, N, Kabus, S, Loo, B, Keall, P, Yamamoto, T
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
BIOMEDICAL RADIOGRAPHY
Cancer
CLINICAL TRIALS
COMPUTERIZED TOMOGRAPHY
DOSE EQUIVALENTS
Dosimetry
IMAGE PROCESSING
Image registration
LUNGS
Medical imaging
NEOPLASMS
PATIENTS
RADIATION DOSES
RADIATION PROTECTION AND DOSIMETRY
RADIOTHERAPY
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Summary:Purpose: To test the hypothesis: 4D‐CT ventilation imaging can show the known effects of radiotherapy on lung function: (1) radiation‐induced ventilation reductions, and (2) ventilation increases caused by tumor regression. Methods: Repeat 4D‐CT scans (pre‐, mid‐ and/or post‐treatment) were acquired prospectively for 11 thoracic cancer patients in an IRB‐approved clinical trial. A ventilation image for each time point was created using deformable image registration and the Hounsfield unit (HU)‐based or Jacobian‐based metric. The 11 patients were divided into two subgroups based on tumor volume reduction using a threshold of 5 cm3. To quantify radiation‐induced ventilation reduction, six patients who showed a small tumor volume reduction (
ISSN:0094-2405
2473-4209
DOI:10.1118/1.4925754