Optimization of oncological {sup 18}F-FDG PET/CT imaging based on a multiparameter analysis

Purpose: This paper describes a method to achieve consistent clinical image quality in {sup 18}F-FDG scans accounting for patient habitus, dose regimen, image acquisition, and processing techniques. Methods: Oncological PET/CT scan data for 58 subjects were evaluated retrospectively to derive analyt...

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Published in:Medical physics (Lancaster) 2016-02, Vol.43 (2)
Main Authors: Menezes, Vinicius O., Machado, Marcos A. D., Queiroz, Cleiton C., Souza, Susana O., D’Errico, Francesco, Namías, Mauro, Larocca, Ticiana F., Soares, Milena B. P.
Format: Article
Language:English
Subjects:
BIOMEDICAL RADIOGRAPHY
COMPUTERIZED TOMOGRAPHY
COUNTING RATES
FLUORINE 18
IMAGE PROCESSING
MULTI-PARAMETER ANALYSIS
OPTIMIZATION
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
RADIATION DOSES
RADIATION PROTECTION AND DOSIMETRY
RADIOLOGY AND NUCLEAR MEDICINE
THREE-BODY PROBLEM
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Summary:Purpose: This paper describes a method to achieve consistent clinical image quality in {sup 18}F-FDG scans accounting for patient habitus, dose regimen, image acquisition, and processing techniques. Methods: Oncological PET/CT scan data for 58 subjects were evaluated retrospectively to derive analytical curves that predict image quality. Patient noise equivalent count rate and coefficient of variation (CV) were used as metrics in their analysis. Optimized acquisition protocols were identified and prospectively applied to 179 subjects. Results: The adoption of different schemes for three body mass ranges (90 kg) allows improved image quality with both point spread function and ordered-subsets expectation maximization-3D reconstruction methods. The application of this methodology showed that CV improved significantly (p < 0.0001) in clinical practice. Conclusions: Consistent oncological PET/CT image quality on a high-performance scanner was achieved from an analysis of the relations existing between dose regimen, patient habitus, acquisition, and processing techniques. The proposed methodology may be used by PET/CT centers to develop protocols to standardize PET/CT imaging procedures and achieve better patient management and cost-effective operations.
ISSN:0094-2405
2473-4209
DOI:10.1118/1.4940354