Theoretical substantiation of biological efficacy enhancement for β-delayed particle decay (9)C beam: A Monte Carlo study in combination with analysis with the local effect model approach

• Published in: Medical physics (Lancaster) 2016-03, Vol.43 (3), p.1200-1221
• Main Authors: Tian, Liheng, Li, Qiang, Liu, Xinguo, Dai, Zhongying, Fu, Tingyan, He, Pengbo, Yan, Yuanlin, Ma, Yuanyuan, Huang, Qiyan
• Format: Article
• Language: English
• Subjects: Algorithms; ANIMAL TISSUES; Beta Particles - therapeutic use; BRAGG CURVE; CARBON 9; CELL NUCLEI; COMPUTERIZED SIMULATION; HEAVY IONS; ION BEAMS; IRRADIATION; MONTE CARLO METHOD; NEOPLASMS; PARTICLE DECAY; RADIATION PROTECTION AND DOSIMETRY; RADIOLOGY AND NUCLEAR MEDICINE; RADIOTHERAPY; RBE; Relative Biological Effectiveness; TUMOR CELLS
• ISSN: 0094-2405; 2473-4209
• DOI: 10.1118/1.4941310

To improve the efficacy of heavy ion therapy, β-delayed particle decay (9)C beam as a double irradiation source for cancer therapy has been proposed. The authors' previous experiment showed that relative biological effectiveness (RBE) values at the depths around the Bragg peak of a (9)C beam were enhanced and compared to its stable counterpart (12)C beam. The purpose of this study was to explore the nature of the biological efficacy enhancement theoretically. A Monte Carlo simulation study was conducted in this study. First a simplified cell model was established so as to form a tumor tissue. Subsequently, the tumor tissue was imported into the Monte Carlo simulation software package gate and then the tumor cells were virtually irradiated with comparable (9)C and (12)C beams, respectively, in the simulations. The transportation and particle deposition data of the (9)C and (12)C beams, derived from the gate simulations, were analyzed with the authors' local effect model implementation so as to deduce cell survival fractions. The particles emitted from the decay process of deposited (9)C particles around a cell nucleus increased the dose delivered to the nucleus and elicited clustered damages around the secondary particles' trajectories. Therefore, compared to the (12)C beam, the RBE value of the (9)C beam increased at the depths around their Bragg peaks. Collectively, the increased local doses and clustered damages due to the decayed particles emitted from deposited (9)C particles led to the RBE enhancement in contrast with the (12)C beam. Thus, the enhanced RBE effect of a (9)C beam for a simplified tumor model was shown theoretically in this study.