Reduced Ang2 expression in aging endothelial cells

Aging endothelial cells are characterized by increased cell size, reduced telomere length and increased expression of proinflammatory cytokines. In addition, we describe here that aging reduces the migratory distance of endothelial cells. Furthermore, we observe an increase of the quiescence protein...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2016-06, Vol.474 (3), p.447-451
Main Authors: Hohensinner, P.J., Ebenbauer, B., Kaun, C., Maurer, G., Huber, K., Wojta, J.
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
AGING
Aging - pathology
Aging - physiology
Angiopoietin
Angiopoietin-1 - metabolism
Angiopoietin-2 - metabolism
Cell Movement - physiology
Cell Proliferation - physiology
Cells, Cultured
Cellular Senescence - physiology
Down-Regulation - physiology
ELDERLY PEOPLE
Endothelial cell
Endothelial Cells - cytology
Endothelial Cells - physiology
Gene Expression Regulation, Developmental - physiology
HEALING
Humans
LYMPHOKINES
Migration
TELOMERES
Wound healing
WOUNDS
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Summary:Aging endothelial cells are characterized by increased cell size, reduced telomere length and increased expression of proinflammatory cytokines. In addition, we describe here that aging reduces the migratory distance of endothelial cells. Furthermore, we observe an increase of the quiescence protein Ang1 and a decrease of the endothelial activation protein Ang2 upon aging. Supplementing Ang2 to aged endothelial cells restored their migratory capacity. We conclude that aging shifts the balance of the Ang1/Ang2 network favouring a quiescent state. Activation of endothelial cells in aging might be necessary to enhance wound healing capacities. •Endothelial cells display signs of aging before reaching proliferative senescence.•Aging endothelial cells express more angiopoietin 1 and less angiopoietin 2 than young endothelial cells.•Migratory capacity is reduced in aging endothelial cells.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2016.04.143