Lead exposure is related to hypercortisolemic profiles and allostatic load in Brazilian older adults

Lead levels (Pb) have been linked to both hyper- and hypo-reactivity of hypothalamic-pituitary-adrenal axis (HPA) axis to acute stress in animals and humans. Similarly, allostatic load (AL), the ‘wear and tear’ of chronic stress, is associated with inadequate HPA axis activity. We examined whether P...

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Bibliographic Details
Published in:Environmental research 2017-04, Vol.154, p.261-268
Main Authors: Souza-Talarico, Juliana N., Suchecki, Deborah, Juster, Robert-Paul, Plusquellec, Pierrich, Barbosa Junior, Fernando, Bunscheit, Vinícius, Marcourakis, Tania, de Matos, Tatiane Martins, Lupien, Sonia J.
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
Aged
Aged, 80 and over
Aging
Aging - drug effects
Allostasis - drug effects
Allostatic load
BIOLOGICAL MARKERS
BIOLOGICAL STRESS
Biomarkers - blood
BLOOD
Blood lead
Brazil
Circadian Rhythm
Cortisol
Cross-Sectional Studies
Cushing Syndrome - etiology
Female
HPA axis
Humans
HYDROCORTISONE
Hydrocortisone - blood
Hypothalamo-Hypophyseal System - drug effects
LEAD
Lead - blood
Lead - toxicity
Male
Middle Aged
Pituitary-Adrenal System - drug effects
US NIOSH
WOMEN
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Summary:Lead levels (Pb) have been linked to both hyper- and hypo-reactivity of hypothalamic-pituitary-adrenal axis (HPA) axis to acute stress in animals and humans. Similarly, allostatic load (AL), the ‘wear and tear’ of chronic stress, is associated with inadequate HPA axis activity. We examined whether Pb levels would be associated with altered diurnal cortisol profile, as a primary mediator of AL, during aging. Pb levels were measured from blood samples (BPb) of 126 Brazilian individuals (105 women), between 50 and 82 years old. Six neuroendocrine, metabolic, and anthropometric biomarkers were analyzed and values were transformed into an AL index using clinical reference cut-offs. Salivary samples were collected at home over 2 days at awakening, 30-min after waking, afternoon, and evening periods to determine cortisol levels. A multiple linear regression model showed a positive association between BPb as the independent continuous variable and cortisol awakening response (R2=0.128; B=0.791; p=0.005) and overall cortisol concentration (R2=0.266; B=0.889; p
ISSN:0013-9351
1096-0953
DOI:10.1016/j.envres.2017.01.012