Effects of two-dimensional materials on human mesenchymal stem cell behaviors

Graphene, a typical two-dimensional (2D) material, is known to affect a variety of stem cell behaviors including adhesion, spreading, growth, and differentiation. Here, we report for the first time the effects of four different emerging 2D materials on human adipose-derived mesenchymal stem cells (h...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2017-11, Vol.493 (1), p.578-584
Main Authors: Suhito, Intan Rosalina, Han, Yoojoong, Kim, Da-Seul, Son, Hyungbin, Kim, Tae-Hyung
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
ADHESION
Adipogenesis
Biocompatible Materials - chemistry
CASTING
Cell Adhesion - physiology
CELL CULTURES
Cell Differentiation - physiology
Cell Movement - physiology
Cell Proliferation - physiology
Cells, Cultured
Differentiation
DROPLETS
Equipment Design
GRAPHENE
Graphite - chemistry
Humans
LIPIDS
Materials Testing
Mesenchymal stem cell
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - physiology
MESSENGER-RNA
MOLYBDENUM
MOLYBDENUM SULFIDES
Osteogenesis
Stem Cell Niche - physiology
STEM CELLS
SUBSTRATES
THERAPY
Tissue Scaffolds
TOXICITY
TUNGSTEN
TUNGSTEN SULFIDES
Two-dimensional material
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Summary:Graphene, a typical two-dimensional (2D) material, is known to affect a variety of stem cell behaviors including adhesion, spreading, growth, and differentiation. Here, we report for the first time the effects of four different emerging 2D materials on human adipose-derived mesenchymal stem cells (hADMSCs). Graphene oxide (GO), molybdenum sulfide (MoS2), tungsten sulfide (WS2), and boron nitride (BN) were selected as model two-dimensional materials and were coated on cell-culture substrates by a drop-casting method. Acute toxicity was not observed with any of the four different 2D materials at a low concentration range (
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2017.08.149