Synthesis of Biodegradable and Blood-Compatible Polyurethane Based on Poly(vinylpyrrolidone)

Three kinds of degradable and blood-compatible polyurethane (PU) were synthesized by coupling hydroxyl-terminated poly(vinylpyrrolidone) (PVP) with diisocyanate-terminated PU. The chemical structure and molecular weight of the synthesized copolymer were systematically characterized by nuclear magnet...

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Bibliographic Details
Published in:Journal of polymers and the environment 2017-12, Vol.25 (4), p.1296-1303
Main Authors: Zhang, Qin, Shi, Xu-Hua, Chen, Han-Jia
Format: Article
Language:English
Subjects:
ABSORPTION
ADSORPTION
Biodegradability
BIODEGRADATION
BLOOD
Chemical synthesis
Chemistry
Chemistry and Materials Science
Compatibility
COPOLYMERS
Coupling (molecular)
Degradability
Degradation
Environmental Chemistry
Environmental Engineering/Biotechnology
FOURIER TRANSFORM SPECTROMETERS
Fourier transforms
GEL PERMEATION CHROMATOGRAPHY
HEMOLYSIS
Industrial Chemistry/Chemical Engineering
Infrared radiation
Infrared spectroscopy
Liquid chromatography
MATERIALS SCIENCE
Molecular structure
MOLECULAR WEIGHT
NMR
NUCLEAR MAGNETIC RESONANCE
Original Paper
Polymer Sciences
Polyurethane
Polyurethane resins
POLYURETHANES
PVP
SYNTHESIS
THIN FILMS
Vinylpyrrolidone
Water absorption
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Description
Summary:Three kinds of degradable and blood-compatible polyurethane (PU) were synthesized by coupling hydroxyl-terminated poly(vinylpyrrolidone) (PVP) with diisocyanate-terminated PU. The chemical structure and molecular weight of the synthesized copolymer were systematically characterized by nuclear magnetic resonance spectrum ( 1 HNMR), Fourier transform infrared spectroscopy (FTIR) and gel permeation chromatography (GPC). The hydrophilicity and water absorption of the synthesized PU was increased by introducing PVP segment. To evaluate the hemocompatibility and degradability of the modified PU films, the extent of platelet adsorption, plasma recalcification time, hemolysis and degradation were measured. All results indicated that the blood compatibility and degradability of the PU films were improved significantly after introduction PVP segment into PU.
ISSN:1566-2543
1572-8919
1572-8900
DOI:10.1007/s10924-016-0907-z