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Synthesis of Biodegradable and Blood-Compatible Polyurethane Based on Poly(vinylpyrrolidone)
Three kinds of degradable and blood-compatible polyurethane (PU) were synthesized by coupling hydroxyl-terminated poly(vinylpyrrolidone) (PVP) with diisocyanate-terminated PU. The chemical structure and molecular weight of the synthesized copolymer were systematically characterized by nuclear magnet...
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| Published in: | Journal of polymers and the environment 2017-12, Vol.25 (4), p.1296-1303 |
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| Main Authors: | , , |
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| cited_by | cdi_FETCH-LOGICAL-c383t-f9d5727c73e81d5b4081cf30b79da6bc51837b1f318ed93623ebd101939c51933 |
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| cites | cdi_FETCH-LOGICAL-c383t-f9d5727c73e81d5b4081cf30b79da6bc51837b1f318ed93623ebd101939c51933 |
| container_end_page | 1303 |
| container_issue | 4 |
| container_start_page | 1296 |
| container_title | Journal of polymers and the environment |
| container_volume | 25 |
| creator | Zhang, Qin Shi, Xu-Hua Chen, Han-Jia |
| description | Three kinds of degradable and blood-compatible polyurethane (PU) were synthesized by coupling hydroxyl-terminated poly(vinylpyrrolidone) (PVP) with diisocyanate-terminated PU. The chemical structure and molecular weight of the synthesized copolymer were systematically characterized by nuclear magnetic resonance spectrum (
1
HNMR), Fourier transform infrared spectroscopy (FTIR) and gel permeation chromatography (GPC). The hydrophilicity and water absorption of the synthesized PU was increased by introducing PVP segment. To evaluate the hemocompatibility and degradability of the modified PU films, the extent of platelet adsorption, plasma recalcification time, hemolysis and degradation were measured. All results indicated that the blood compatibility and degradability of the PU films were improved significantly after introduction PVP segment into PU. |
| doi_str_mv | 10.1007/s10924-016-0907-z |
| format | article |
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1
HNMR), Fourier transform infrared spectroscopy (FTIR) and gel permeation chromatography (GPC). The hydrophilicity and water absorption of the synthesized PU was increased by introducing PVP segment. To evaluate the hemocompatibility and degradability of the modified PU films, the extent of platelet adsorption, plasma recalcification time, hemolysis and degradation were measured. All results indicated that the blood compatibility and degradability of the PU films were improved significantly after introduction PVP segment into PU.</description><identifier>ISSN: 1566-2543</identifier><identifier>EISSN: 1572-8919</identifier><identifier>EISSN: 1572-8900</identifier><identifier>DOI: 10.1007/s10924-016-0907-z</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>ABSORPTION ; ADSORPTION ; Biodegradability ; BIODEGRADATION ; BLOOD ; Chemical synthesis ; Chemistry ; Chemistry and Materials Science ; Compatibility ; COPOLYMERS ; Coupling (molecular) ; Degradability ; Degradation ; Environmental Chemistry ; Environmental Engineering/Biotechnology ; FOURIER TRANSFORM SPECTROMETERS ; Fourier transforms ; GEL PERMEATION CHROMATOGRAPHY ; HEMOLYSIS ; Industrial Chemistry/Chemical Engineering ; Infrared radiation ; Infrared spectroscopy ; Liquid chromatography ; MATERIALS SCIENCE ; Molecular structure ; MOLECULAR WEIGHT ; NMR ; NUCLEAR MAGNETIC RESONANCE ; Original Paper ; Polymer Sciences ; Polyurethane ; Polyurethane resins ; POLYURETHANES ; PVP ; SYNTHESIS ; THIN FILMS ; Vinylpyrrolidone ; Water absorption</subject><ispartof>Journal of polymers and the environment, 2017-12, Vol.25 (4), p.1296-1303</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>Journal of Polymers and the Environment is a copyright of Springer, (2016). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-f9d5727c73e81d5b4081cf30b79da6bc51837b1f318ed93623ebd101939c51933</citedby><cites>FETCH-LOGICAL-c383t-f9d5727c73e81d5b4081cf30b79da6bc51837b1f318ed93623ebd101939c51933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.osti.gov/biblio/22788355$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Qin</creatorcontrib><creatorcontrib>Shi, Xu-Hua</creatorcontrib><creatorcontrib>Chen, Han-Jia</creatorcontrib><title>Synthesis of Biodegradable and Blood-Compatible Polyurethane Based on Poly(vinylpyrrolidone)</title><title>Journal of polymers and the environment</title><addtitle>J Polym Environ</addtitle><description>Three kinds of degradable and blood-compatible polyurethane (PU) were synthesized by coupling hydroxyl-terminated poly(vinylpyrrolidone) (PVP) with diisocyanate-terminated PU. The chemical structure and molecular weight of the synthesized copolymer were systematically characterized by nuclear magnetic resonance spectrum (
1
HNMR), Fourier transform infrared spectroscopy (FTIR) and gel permeation chromatography (GPC). The hydrophilicity and water absorption of the synthesized PU was increased by introducing PVP segment. To evaluate the hemocompatibility and degradability of the modified PU films, the extent of platelet adsorption, plasma recalcification time, hemolysis and degradation were measured. All results indicated that the blood compatibility and degradability of the PU films were improved significantly after introduction PVP segment into PU.</description><subject>ABSORPTION</subject><subject>ADSORPTION</subject><subject>Biodegradability</subject><subject>BIODEGRADATION</subject><subject>BLOOD</subject><subject>Chemical synthesis</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Compatibility</subject><subject>COPOLYMERS</subject><subject>Coupling (molecular)</subject><subject>Degradability</subject><subject>Degradation</subject><subject>Environmental Chemistry</subject><subject>Environmental Engineering/Biotechnology</subject><subject>FOURIER TRANSFORM SPECTROMETERS</subject><subject>Fourier transforms</subject><subject>GEL PERMEATION CHROMATOGRAPHY</subject><subject>HEMOLYSIS</subject><subject>Industrial Chemistry/Chemical Engineering</subject><subject>Infrared radiation</subject><subject>Infrared spectroscopy</subject><subject>Liquid chromatography</subject><subject>MATERIALS SCIENCE</subject><subject>Molecular structure</subject><subject>MOLECULAR WEIGHT</subject><subject>NMR</subject><subject>NUCLEAR MAGNETIC RESONANCE</subject><subject>Original Paper</subject><subject>Polymer Sciences</subject><subject>Polyurethane</subject><subject>Polyurethane resins</subject><subject>POLYURETHANES</subject><subject>PVP</subject><subject>SYNTHESIS</subject><subject>THIN FILMS</subject><subject>Vinylpyrrolidone</subject><subject>Water absorption</subject><issn>1566-2543</issn><issn>1572-8919</issn><issn>1572-8900</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kM1KxDAUhYsoOI4-gLuCG11Ek6ZpkqUz-AeCgroTQpqkMxk6SU0yQufpbR1BN67u5d5zDocvy04RvEQQ0quIIC9KAFEFIIcUbPeyCSK0AIwjvj_uVQUKUuLD7CjGFYSQD75J9v7Su7Q00cbcN_nMem0WQWpZtyaXTuez1nsN5n7dyWTH47Nv-00waSmdyWcyGp179309_7Sub7s-BN9a7Z25OM4OGtlGc_Izp9nb7c3r_B48Pt09zK8fgcIMJ9BwPTSlimLDkCZ1CRlSDYY15VpWtSKIYVqjBiNmNMdVgU2tEUQc8-HHMZ5mZ7tcH5MVUdlk1FJ554xKoigoY5iQX1UX_MfGxCRWfhPcUEwgXpUloZSMWWinUsHHGEwjumDXMvQCQTGiFjvUYkAtRtRiO3iKnScOWrcw4U_yv6YvOmmBQA</recordid><startdate>20171201</startdate><enddate>20171201</enddate><creator>Zhang, Qin</creator><creator>Shi, Xu-Hua</creator><creator>Chen, Han-Jia</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7SR</scope><scope>7XB</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>M2P</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>OTOTI</scope></search><sort><creationdate>20171201</creationdate><title>Synthesis of Biodegradable and Blood-Compatible Polyurethane Based on Poly(vinylpyrrolidone)</title><author>Zhang, Qin ; Shi, Xu-Hua ; Chen, Han-Jia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-f9d5727c73e81d5b4081cf30b79da6bc51837b1f318ed93623ebd101939c51933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>ABSORPTION</topic><topic>ADSORPTION</topic><topic>Biodegradability</topic><topic>BIODEGRADATION</topic><topic>BLOOD</topic><topic>Chemical synthesis</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Compatibility</topic><topic>COPOLYMERS</topic><topic>Coupling (molecular)</topic><topic>Degradability</topic><topic>Degradation</topic><topic>Environmental Chemistry</topic><topic>Environmental Engineering/Biotechnology</topic><topic>FOURIER TRANSFORM SPECTROMETERS</topic><topic>Fourier transforms</topic><topic>GEL PERMEATION CHROMATOGRAPHY</topic><topic>HEMOLYSIS</topic><topic>Industrial Chemistry/Chemical Engineering</topic><topic>Infrared radiation</topic><topic>Infrared spectroscopy</topic><topic>Liquid chromatography</topic><topic>MATERIALS SCIENCE</topic><topic>Molecular structure</topic><topic>MOLECULAR WEIGHT</topic><topic>NMR</topic><topic>NUCLEAR MAGNETIC RESONANCE</topic><topic>Original Paper</topic><topic>Polymer Sciences</topic><topic>Polyurethane</topic><topic>Polyurethane resins</topic><topic>POLYURETHANES</topic><topic>PVP</topic><topic>SYNTHESIS</topic><topic>THIN FILMS</topic><topic>Vinylpyrrolidone</topic><topic>Water absorption</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Qin</creatorcontrib><creatorcontrib>Shi, Xu-Hua</creatorcontrib><creatorcontrib>Chen, Han-Jia</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Engineered Materials Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>Science Database</collection><collection>Environmental Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>OSTI.GOV</collection><jtitle>Journal of polymers and the environment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Qin</au><au>Shi, Xu-Hua</au><au>Chen, Han-Jia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of Biodegradable and Blood-Compatible Polyurethane Based on Poly(vinylpyrrolidone)</atitle><jtitle>Journal of polymers and the environment</jtitle><stitle>J Polym Environ</stitle><date>2017-12-01</date><risdate>2017</risdate><volume>25</volume><issue>4</issue><spage>1296</spage><epage>1303</epage><pages>1296-1303</pages><issn>1566-2543</issn><eissn>1572-8919</eissn><eissn>1572-8900</eissn><abstract>Three kinds of degradable and blood-compatible polyurethane (PU) were synthesized by coupling hydroxyl-terminated poly(vinylpyrrolidone) (PVP) with diisocyanate-terminated PU. The chemical structure and molecular weight of the synthesized copolymer were systematically characterized by nuclear magnetic resonance spectrum (
1
HNMR), Fourier transform infrared spectroscopy (FTIR) and gel permeation chromatography (GPC). The hydrophilicity and water absorption of the synthesized PU was increased by introducing PVP segment. To evaluate the hemocompatibility and degradability of the modified PU films, the extent of platelet adsorption, plasma recalcification time, hemolysis and degradation were measured. All results indicated that the blood compatibility and degradability of the PU films were improved significantly after introduction PVP segment into PU.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10924-016-0907-z</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of polymers and the environment, 2017-12, Vol.25 (4), p.1296-1303 |
| issn | 1566-2543 1572-8919 1572-8900 |
| language | eng |
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| source | Springer Nature |
| subjects | ABSORPTION ADSORPTION Biodegradability BIODEGRADATION BLOOD Chemical synthesis Chemistry Chemistry and Materials Science Compatibility COPOLYMERS Coupling (molecular) Degradability Degradation Environmental Chemistry Environmental Engineering/Biotechnology FOURIER TRANSFORM SPECTROMETERS Fourier transforms GEL PERMEATION CHROMATOGRAPHY HEMOLYSIS Industrial Chemistry/Chemical Engineering Infrared radiation Infrared spectroscopy Liquid chromatography MATERIALS SCIENCE Molecular structure MOLECULAR WEIGHT NMR NUCLEAR MAGNETIC RESONANCE Original Paper Polymer Sciences Polyurethane Polyurethane resins POLYURETHANES PVP SYNTHESIS THIN FILMS Vinylpyrrolidone Water absorption |
| title | Synthesis of Biodegradable and Blood-Compatible Polyurethane Based on Poly(vinylpyrrolidone) |
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