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Experimental study of the antitumor effect of aurumacryl
Gold polyacrylate (aurumacryl) belonging to a new class of compounds for oncology — metal polyacrylates — was shown to exhibit strong antitumor activity. Aurumacryl causes 80—90% growth inhibition in vivo of murine solid tumors (Lewis lung carcinoma, Ca-755 adenocarcinoma, and Acatol adenocarcinoma)...
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| Published in: | Russian chemical bulletin 2017-12, Vol.66 (12), p.2333-2338 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c344t-9c7131be19904a8643540b827adb5800fe43789fd9fd5b6541b4a457b5af178a3 |
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| cites | cdi_FETCH-LOGICAL-c344t-9c7131be19904a8643540b827adb5800fe43789fd9fd5b6541b4a457b5af178a3 |
| container_end_page | 2338 |
| container_issue | 12 |
| container_start_page | 2333 |
| container_title | Russian chemical bulletin |
| container_volume | 66 |
| creator | Ostrovskaya, L. A. Korman, D. B. Grehova, A. K. Osipov, A. N. Bluhterova, N. V. Fomina, M. M. Rikova, V. A. Abzaeva, K. A. |
| description | Gold polyacrylate (aurumacryl) belonging to a new class of compounds for oncology — metal polyacrylates — was shown to exhibit strong antitumor activity. Aurumacryl causes 80—90% growth inhibition
in vivo
of murine solid tumors (Lewis lung carcinoma, Ca-755 adenocarcinoma, and Acatol adenocarcinoma) compared to the control and induces cell death
in vitro
in 60% of MCF-7 human breast carcinoma cells. Substantial changes in proliferation kinetics of the surviving fraction of tumor cells following treatment with aurumacryl were observed, which are related to the predominant accumulation (93%) of cells in the proliferative resting phase G
0
and a substantial decrease in the percentage of proliferating cells (7%). These data provide evidence that the cells that survive lose reproductive ability under treatment with aurumacryl. |
| doi_str_mv | 10.1007/s11172-017-2025-z |
| format | article |
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in vivo
of murine solid tumors (Lewis lung carcinoma, Ca-755 adenocarcinoma, and Acatol adenocarcinoma) compared to the control and induces cell death
in vitro
in 60% of MCF-7 human breast carcinoma cells. Substantial changes in proliferation kinetics of the surviving fraction of tumor cells following treatment with aurumacryl were observed, which are related to the predominant accumulation (93%) of cells in the proliferative resting phase G
0
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in vivo
of murine solid tumors (Lewis lung carcinoma, Ca-755 adenocarcinoma, and Acatol adenocarcinoma) compared to the control and induces cell death
in vitro
in 60% of MCF-7 human breast carcinoma cells. Substantial changes in proliferation kinetics of the surviving fraction of tumor cells following treatment with aurumacryl were observed, which are related to the predominant accumulation (93%) of cells in the proliferative resting phase G
0
and a substantial decrease in the percentage of proliferating cells (7%). These data provide evidence that the cells that survive lose reproductive ability under treatment with aurumacryl.</description><subject>60 APPLIED LIFE SCIENCES</subject><subject>Acrylic resins</subject><subject>Anticancer properties</subject><subject>APOPTOSIS</subject><subject>BUILDUP</subject><subject>CARCINOMAS</subject><subject>Cell death</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>CHEMOTHERAPY</subject><subject>CONTROL</subject><subject>Full Article</subject><subject>GOLD</subject><subject>IN VITRO</subject><subject>IN VIVO</subject><subject>Inorganic Chemistry</subject><subject>INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY</subject><subject>LUNGS</subject><subject>MAMMARY GLANDS</subject><subject>Organic Chemistry</subject><subject>POLYACRYLATES</subject><subject>TUMOR CELLS</subject><issn>1066-5285</issn><issn>1573-9171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kEFLAzEQhYMoWKs_wNuC5-hMNtlkj1KqFQpe9ByyaWK3tLs1yYLtrzdlhZ6EgRmG7w1vHiH3CI8IIJ8iIkpGASVlwAQ9XpAJClnSGiVe5hmqigqmxDW5iXEDAEwpNSFq_rN3od25LpltEdOwOhS9L9LaFaZLbRp2fSic986m094MYdgZGw7bW3LlzTa6u78-JZ8v84_Zgi7fX99mz0tqS84Tra3EEhuHdQ3cqIqXgkOjmDSrRigA73gpVe1XuURTCY4NN1zIRhiPUplySh7Gu31MrY62Tc6ubd912ZFmTFUlR3Wm9qH_HlxMetMPocvGNAPkmanrKlM4Ujb0MQbn9T6_bsJBI-hTjHqMUecY9SlGfcwaNmpiZrsvF86X_xf9Arf4c94</recordid><startdate>20171201</startdate><enddate>20171201</enddate><creator>Ostrovskaya, L. A.</creator><creator>Korman, D. B.</creator><creator>Grehova, A. K.</creator><creator>Osipov, A. N.</creator><creator>Bluhterova, N. V.</creator><creator>Fomina, M. M.</creator><creator>Rikova, V. A.</creator><creator>Abzaeva, K. A.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>20171201</creationdate><title>Experimental study of the antitumor effect of aurumacryl</title><author>Ostrovskaya, L. A. ; Korman, D. B. ; Grehova, A. K. ; Osipov, A. N. ; Bluhterova, N. V. ; Fomina, M. M. ; Rikova, V. A. ; Abzaeva, K. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-9c7131be19904a8643540b827adb5800fe43789fd9fd5b6541b4a457b5af178a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>60 APPLIED LIFE SCIENCES</topic><topic>Acrylic resins</topic><topic>Anticancer properties</topic><topic>APOPTOSIS</topic><topic>BUILDUP</topic><topic>CARCINOMAS</topic><topic>Cell death</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>CHEMOTHERAPY</topic><topic>CONTROL</topic><topic>Full Article</topic><topic>GOLD</topic><topic>IN VITRO</topic><topic>IN VIVO</topic><topic>Inorganic Chemistry</topic><topic>INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY</topic><topic>LUNGS</topic><topic>MAMMARY GLANDS</topic><topic>Organic Chemistry</topic><topic>POLYACRYLATES</topic><topic>TUMOR CELLS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ostrovskaya, L. A.</creatorcontrib><creatorcontrib>Korman, D. B.</creatorcontrib><creatorcontrib>Grehova, A. K.</creatorcontrib><creatorcontrib>Osipov, A. N.</creatorcontrib><creatorcontrib>Bluhterova, N. V.</creatorcontrib><creatorcontrib>Fomina, M. M.</creatorcontrib><creatorcontrib>Rikova, V. A.</creatorcontrib><creatorcontrib>Abzaeva, K. A.</creatorcontrib><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Russian chemical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ostrovskaya, L. A.</au><au>Korman, D. B.</au><au>Grehova, A. K.</au><au>Osipov, A. N.</au><au>Bluhterova, N. V.</au><au>Fomina, M. M.</au><au>Rikova, V. A.</au><au>Abzaeva, K. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental study of the antitumor effect of aurumacryl</atitle><jtitle>Russian chemical bulletin</jtitle><stitle>Russ Chem Bull</stitle><date>2017-12-01</date><risdate>2017</risdate><volume>66</volume><issue>12</issue><spage>2333</spage><epage>2338</epage><pages>2333-2338</pages><issn>1066-5285</issn><eissn>1573-9171</eissn><abstract>Gold polyacrylate (aurumacryl) belonging to a new class of compounds for oncology — metal polyacrylates — was shown to exhibit strong antitumor activity. Aurumacryl causes 80—90% growth inhibition
in vivo
of murine solid tumors (Lewis lung carcinoma, Ca-755 adenocarcinoma, and Acatol adenocarcinoma) compared to the control and induces cell death
in vitro
in 60% of MCF-7 human breast carcinoma cells. Substantial changes in proliferation kinetics of the surviving fraction of tumor cells following treatment with aurumacryl were observed, which are related to the predominant accumulation (93%) of cells in the proliferative resting phase G
0
and a substantial decrease in the percentage of proliferating cells (7%). These data provide evidence that the cells that survive lose reproductive ability under treatment with aurumacryl.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11172-017-2025-z</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 1066-5285 |
| ispartof | Russian chemical bulletin, 2017-12, Vol.66 (12), p.2333-2338 |
| issn | 1066-5285 1573-9171 |
| language | eng |
| recordid | cdi_osti_scitechconnect_22863418 |
| source | Springer Nature |
| subjects | 60 APPLIED LIFE SCIENCES Acrylic resins Anticancer properties APOPTOSIS BUILDUP CARCINOMAS Cell death Chemistry Chemistry and Materials Science Chemistry/Food Science CHEMOTHERAPY CONTROL Full Article GOLD IN VITRO IN VIVO Inorganic Chemistry INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY LUNGS MAMMARY GLANDS Organic Chemistry POLYACRYLATES TUMOR CELLS |
| title | Experimental study of the antitumor effect of aurumacryl |
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