Cryochemical synthesis and antibacterial activity of hybrid nanocomposites based on dioxidine containing Ag and Cu nanoparticles incorporated in biopolymer cryostructurates

Cryochemical synthesis of hybrid nanocomposites based on the antibacterial drug, dioxidine, and metals (Ag, Cu) was performed. According to the data of H 1 NMR, UV, and IR spectroscopy, low-temperature argon sorption, and transmission electron microscopy, met-als in these systems exist as Ag nanopar...

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Bibliographic Details
Published in:Russian chemical bulletin 2017-11, Vol.66 (11), p.2152-2156
Main Authors: Vernaya, O. I., Shabatin, V. P., Nuzhdina, A. V., Zvukova, N. D., Khvatov, D. I., Semenov, A. M., Lozinskii, V. I., Shabatina, T. I., Melnikov, M. Ya
Format: Article
Language:English
Subjects:
ALGINATES
ANTIBIOTICS
ARGON
Biopolymers
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
COPPER
Drug delivery systems
E coli
Electron microscopy
ESCHERICHIA COLI
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HYBRIDIZATION
HYDROGEN 1
INFRARED SPECTRA
Infrared spectroscopy
Inorganic Chemistry
Microorganisms
MYCOBACTERIUM
NANOCOMPOSITES
NANOPARTICLES
NANOSCIENCE AND NANOTECHNOLOGY
NMR
NUCLEAR MAGNETIC RESONANCE
Organic Chemistry
SILVER
SORPTION
STAPHYLOCOCCUS
SYNTHESIS
TRANSMISSION ELECTRON MICROSCOPY
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Summary:Cryochemical synthesis of hybrid nanocomposites based on the antibacterial drug, dioxidine, and metals (Ag, Cu) was performed. According to the data of H 1 NMR, UV, and IR spectroscopy, low-temperature argon sorption, and transmission electron microscopy, met-als in these systems exist as Ag nanoparticles (with dimensions of 2—30 nm) or Cu nanoparti-cles (10—40 nm) involved in the bigger-sized particles of dioxidine with dimensions of 50—350 nm. These hybrid nanocomposites show the enhanced antibacterial activity towards the microbial cells Escherichia coli 52, Staphylococcus aureus 144, Mycobacterium cyaneum 98. The as-prepared drug nanocomposites are incorporated into spongy alginate cryostructurates. The feasibility of drug release from the biopolymer alginate carrier is proved and the related antibacterial activity is demonstrated.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-017-1996-0