Low dose administration of Bisphenol A induces liver toxicity in adult rats

Bisphenol A (BPA) is one of the most widely used chemicals, often used in epoxy resins, health products and colors. This study aims to investigate the effect of various doses of BPA on hepatotoxicity in rats. This experimental study was conducted using 20 male adult Wistar rats older than 2 months w...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2017-12, Vol.494 (1-2), p.107-112
Main Authors: Kazemi, Sohrab, Mousavi Kani, Seydeh Narges, Rezazadeh, Leyla, Pouramir, Mahdi, Ghasemi-Kasman, Maryam, Moghadamnia, Ali Akbar
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
AGGLOMERATION
Alanine Transaminase - blood
Alkaline Phosphatase - blood
ANIMAL TISSUES
Animals
Aspartate Aminotransferases - blood
Benzhydryl Compounds - administration & dosage
Benzhydryl Compounds - toxicity
BIOLOGICAL STRESS
Bisphenol A
CELL NUCLEI
DAMAGE
Dose-Response Relationship, Drug
DOSES
ELECTROPHORESIS
Environmental Pollutants - administration & dosage
Environmental Pollutants - toxicity
EPOXIDES
Hepatotoxicity
INFLAMMATION
LIVER
Liver - drug effects
Liver - metabolism
Liver - pathology
Liver damage
Male
NECROSIS
OXIDATION
Oxidative stress
Oxidative Stress - drug effects
Phenols - administration & dosage
Phenols - toxicity
Protein electrophoresis
PROTEINS
RATS
Rats, Wistar
RESINS
TOXICITY
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Summary:Bisphenol A (BPA) is one of the most widely used chemicals, often used in epoxy resins, health products and colors. This study aims to investigate the effect of various doses of BPA on hepatotoxicity in rats. This experimental study was conducted using 20 male adult Wistar rats older than 2 months weighing 150–200 g. (5, 25 and 125 μg/kg) BPA was administered by gavage for 35 consecutive days. The animals were weighed at the beginning and the end of the experiment. The level of aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase were determined using colorimetric method. The liver tissue was kept in the freezer at −80 °C for histological studies. The body weight of rats receiving BPA decreased significantly compared to control group and this weight loss was more evident at doses of 25 and 125 μg/kg (p 
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2017.10.074