Dark Conductivity and Photoconductivity of Nonaqueous Liposomes: a New Method for Measuring the Phase-Transition Temperatures of Lipid Membranes

A new method is developed to measure the phase-transition temperatures in artificial phospholipid membranes. This method is based on studying the temperature dependence of dark conductivity and photoconductivity in a symmetric cell with current-conducting indium–tin oxide (ITO) electrodes. Internal...

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Bibliographic Details
Published in:Journal of experimental and theoretical physics 2018-10, Vol.127 (4), p.791-796
Main Authors: Yablonskii, S. V., Bodnarchuk, V. V.
Format: Article
Language:English
Subjects:
Biocompatibility
CARRIER MOBILITY
Classical and Quantum Gravitation
COMPARATIVE EVALUATIONS
CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY
Drug carriers
Electrodes
Elementary Particles
Ethylene glycol
ETHYLENE GLYCOLS
GLYCEROL
INDIUM OXIDES
Indium tin oxides
LAYERS
Lipids
Liposomes
LIQUID CRYSTALS
Membranes
Nonlinear
Particle and Nuclear Physics
PHASE TRANSFORMATIONS
Phase transitions
PHOSPHOLIPIDS
PHOTOCONDUCTIVITY
Photoelectric emission
PHOTOEMISSION
Physics
Physics and Astronomy
Positive temperature coefficient
Quantum Field Theory
Relativity Theory
Soft Matter Physics
Solid State Physics
Statistical
SYMMETRY
Temperature
TEMPERATURE DEPENDENCE
TIME-OF-FLIGHT METHOD
Tin
TIN OXIDES
TRANSITION TEMPERATURE
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Summary:A new method is developed to measure the phase-transition temperatures in artificial phospholipid membranes. This method is based on studying the temperature dependence of dark conductivity and photoconductivity in a symmetric cell with current-conducting indium–tin oxide (ITO) electrodes. Internal electron photoemission into a thin liposome layer is induced by visible and near IR light from the ITO electrodes. This method is applied to study the lyotropic phases in 1,2-dipalmitoyl-rac-glycero-3-phosphocholine (DPPC) and 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) with ethylene glycol (EG) and glycerol (G). The results of time-of-flight measurements are used to calculate the carrier mobilities in liposome vesicles. The measurement results are compared with the results obtained by dc conductometry. We are the first to detect the effect of a positive temperature coefficient of resistivity in a liquid-crystal phase. The proposed method makes it possible to detect the phase transitions in lyotropic liquid-crystal systems and, hence, can be used to create biocompatible drug carriers based on thermosensitive liposomes.
ISSN:1063-7761
1090-6509
DOI:10.1134/S1063776118100229