{sup 68}Ga-PSMA-11 PET/CT in newly diagnosed prostate cancer: diagnostic sensitivity and interobserver agreement

• Published in: Abdominal radiology (New York) 2019-07, Vol.44 (7)
• Main Authors: Basha, Mohammad Abd Alkhalik, Hamed, Maged Abdel Galil, Hussein, Omar, El-Diasty, Tarek, Abdelkhalek, Yasser Ibrahim, Hussein, Yehia Omar, Alasamer, Ahmed Fathy, Mohamed, Heba A. E., Deen, Dalia Salah El, Tantawy, Engy Fathy, Metwally, Maha Ibrahim, Zaitoun, Mohamed M. A., Aly, Sameh Abdelaziz, Altohamy, Jehan Ibrahim, Mohamed, Abd El Motaleb, Afifi, Amira Hamed Mohamed, Harb, Ola
• Format: Article
• Language: English
• Subjects: ANTIGENS; DIAGNOSIS; GALLIUM 68; MEMBRANES; METASTASES; NEOPLASMS; PATIENTS; POSITRON COMPUTED TOMOGRAPHY; PROSTATE; RADIOLOGY AND NUCLEAR MEDICINE; UPTAKE
• ISSN: 2366-0058; 2366-0058
• DOI: 10.1007/s00261-019-02006-2

Purpose: To determine the diagnostic sensitivity and interobserver agreement of Gallium 68-prostate-specific membrane antigen positron emission tomography/computed tomography ({sup 68}Ga-PSMA-11 PET/CT) imaging for diagnosis and staging of patients with newly diagnosed prostate cancer (PC). Materials and methods: One hundred and seventy-three men (mean age, 68 ± 7.7 years; range 46–84 years) with newly diagnosed, untreated PC were enrolled in this prospective study between January 2017 and August 2018. All patients underwent a {sup 68}Ga-PSMA-11 PET/CT examination. For each patient, we determined the disease stage, the Gleason score, and the maximum standardized uptake value (SUVmax) for primary prostatic tumor and extraprostatic metastases. The diagnostic sensitivity and interobserver agreement of {sup 68}Ga-PSMA-11 PET/CT for diagnosis and staging of PC were established by histopathology as the reference standard. Results: {sup 68}Ga-PSMA-11 PET/CT examinations were interpreted as positive for PC in 166 of 173 patients (101 patients had primary prostatic tumor only, two patients had extraprostatic metastases only and 63 patients had combined lesions). The sensitivity of {sup 68}Ga-PSMA-11 PET/CT examination in the diagnosis of PC was 96%. {sup 68}Ga-PSMA-11 PET/CT produced a significant change of stage in 28.6% patients with an upstage in 17.9% patients and a downstage in 10.7% patients. The interobserver agreements were almost good to perfect (k = 0.63–0.89) for visual image interpretation, SUVmax measurement, and tumor staging. Conclusion: {sup 68}Ga-PSMA-11 PET/CT is a valuable tool with high diagnostic sensitivity (96%) and high reproducibility for diagnosis and staging of patients with newly diagnosed PC.