Evaluation of acoustic radiation force impulse (ARFI) elastography as non-invasive diagnostic tool in living donor liver transplantation

• Published in: Abdominal imaging 2019-02, Vol.44 (2), p.464-472
• Main Authors: Abdelhaleem, Hanan, Gamal Eldeen, Hadeel, Nabeel, Mohammed Mahmoud, Abdelmoniem, Reham, Elakel, Wafaa, Zayed, Naglaa, Abdellatif, Zeinab, Monir, Bahaa, Abdelaziz, Mohamed Said, Mogawer, Sherif, Elamir, Mona, Elshazli, Mostafa, Salah, Ayman, Hosny, Adel, Yosry, Ayman
• Format: Article
• Language: English
• Subjects: ACOUSTICS; Adult; Background radiation; BIOPSY; Cross-Sectional Studies; Diagnostic software; Diagnostic systems; Elasticity Imaging Techniques - methods; Female; FIBROSIS; Gastroenterology; GRAFTS; Hepatology; Humans; Imaging; LIVER; Liver - diagnostic imaging; Liver - pathology; Liver Diseases - diagnostic imaging; Liver Diseases - pathology; Liver Transplantation; Liver transplants; Living Donors; Male; Males; Medical diagnosis; Medicine; Medicine & Public Health; Middle Aged; Organ donors; Patients; Postoperative Complications - diagnostic imaging; Postoperative Complications - pathology; PULSES; Radiation; Radiology; RADIOLOGY AND NUCLEAR MEDICINE; Reproducibility of Results; Sensitivity and Specificity; Severity of Illness Index; Sound waves; Stiffness; Transplantation; Transplants & implants; Ultrasound; Young Adult
• ISSN: 2366-004X; 2366-0058; 2366-0058
• DOI: 10.1007/s00261-018-1732-8

Background and aims Role of acoustic radiation force impulse (ARFI) elastography, in transplant setting, is not well established. We aimed to define the normal mean values of the liver stiffness by ARFI Elastography in healthy liver donors and to evaluate ARFI elastography as predictor of graft fibrosis post living donor liver transplant (LDLT) in comparison to other non-invasive methods (transient elastography [TE], APRI and FIB4). Patients and methods A total of 100 subjects (70 recipients and 30 donors) were recruited. APRI and FIB4 scores were calculated for all recipients. TE and ARFI elastography (Siemens Acuson S2000 Ultrasound System, Germany) were performed to all subjects. All donors and only 30 recipients had liver biopsy. Significant fibrosis was defined as ≥ F2. Results The mean ARFI velocity among the donors was 1.05 ± 0.09 m/s. Regarding the recipients: mean age was 49.5 ± 8.49 years, 85.7% males, fibrosis stages