Real-Time and Online Monitoring of Glucose Contents by Using Molecular Imprinted Polymer-Based IDEs Sensor

A highly sensitive, selective, reversible, and reusable glucose sensor is developed by using molecularly imprinted polymer-based artificial receptors onto interdigital transducer. Sensor receptors were synthesized through bulk imprinting technology by using styrene as monomer, ethylene glycol dimeth...

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Bibliographic Details
Published in:Applied biochemistry and biotechnology 2019-12, Vol.189 (4), p.1156-1166
Main Authors: Asghar, Nazia, Mustafa, Ghulam, Yasinzai, Maimoona, Al-Soud, Yaseen A., Lieberzeit, Peter A., Latif, Usman
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
Biochemistry
Biosensing Techniques
Biotechnology
Chemistry
Chemistry and Materials Science
Crosslinking
DETECTION
DRUGS
Error detection
Ethylene glycol
ETHYLENE GLYCOLS
FOOD
Food industry
Free radicals
GLUCOSE
Glucose - analysis
Methacrylates - chemistry
Molecular Imprinting
MONITORING
Pharmaceutical industry
POLYMERS
RECEPTORS
Regeneration
SCANNING ELECTRON MICROSCOPY
SENSORS
STYRENE
Styrene - chemistry
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Summary:A highly sensitive, selective, reversible, and reusable glucose sensor is developed by using molecularly imprinted polymer-based artificial receptors onto interdigital transducer. Sensor receptors were synthesized through bulk imprinting technology by using styrene as monomer, ethylene glycol dimethacrylate (EGDMA) as cross-linker, and AIBN as free radical initiator. Topography of the synthesized receptors was investigated by scanning electron microscopy (SEM). Fabricated sensor showed concentration-dependent linear and reversible response with lower limit of detection of 30 ppb and upper limit of detection ~ 500 ppm. Furthermore, newly fabricated sensor is highly selective towards its analyte of interest in the presence of other competing agents, and the regeneration of sensor response has been assessed with the percentage error of less than 2% under the period of 1 year at room temperature and pressure conditions. The reported sensor may have potential technological applications in the field of medical diagnostics, food, and pharmaceutical industry.
ISSN:0273-2289
1559-0291
DOI:10.1007/s12010-019-03049-3