Clinical Significance of {sup 18}F-Fluorodeoxyglucose-Positron Emission Tomography-Positive Lymph Nodes to Outcomes of Trimodal Therapy for Esophageal Squamous Cell Carcinoma

Background: The clinical significance of lymph node (LN) status determined by preoperative {sup 18}F-fluorodeoxyglucose-positron emission tomography (FDG-PET) has not been investigated in patients with locally advanced esophageal squamous cell carcinoma (ESCC) treated with neoadjuvant chemoradiother...

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Bibliographic Details
Published in:Annals of surgical oncology 2019-06, Vol.26 (6)
Main Authors: Hamai, Yoichi, Hihara, Jun, Emi, Manabu, Ibuki, Yuta, Murakami, Yuji, Nishibuchi, Ikuno, Nagata, Yasushi, Aoki, Yoshiro, Furukawa, Takaoki, Okada, Morihito
Format: Article
Language:English
Subjects:
CARCINOMAS
COMBINED THERAPY
ESOPHAGUS
FLUORINE 18
FLUORODEOXYGLUCOSE
FORECASTING
HAZARDS
LYMPH NODES
METASTASES
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
RADIOLOGY AND NUCLEAR MEDICINE
SURGERY
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Summary:Background: The clinical significance of lymph node (LN) status determined by preoperative {sup 18}F-fluorodeoxyglucose-positron emission tomography (FDG-PET) has not been investigated in patients with locally advanced esophageal squamous cell carcinoma (ESCC) treated with neoadjuvant chemoradiotherapy (NCRT) followed by surgery (trimodal therapy). Methods: This study reviewed 132 consecutive patients with ESCC who had been preoperatively evaluated using FDG-PET before and after NCRT to analyze associations among LN status according to PET findings, pathologic LN metastasis, and prognosis of ESCC after trimodal therapy. Results: Lymph nodes that were PET-positive both before and after NCRT comprised significant predictive markers of pathologic LN metastasis in station-by-station analyses (sensitivity, specificity, and accuracy respectively 41.7%, 95.0%, and 92.7% before, and 12.0%, 99.4%, and 95.6% after NCRT; both p 
ISSN:1534-4681
1534-4681
DOI:10.1245/s10434-019-07158-5