Drug with Neuroprotective Properties Noopept Does Not Stimulate Cell Proliferation

Effects of Noopept ( N -phenylacetyl- L -prolylglycine ethyl ester) on the relative level of proliferation marker Ki-67 and cell cycle parameters were studied in HEK293 and SH-SY5Y cell lines. The previously established multifactorial mechanism of action of the drug includes enhancement of neurotrop...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2019-02, Vol.166 (4), p.466-468
Main Authors: Zainullina, L. F., Ivanova, T. V., Ostrovskaya, R. U., Gudasheva, T. A., Vakhitova, Yu. V., Seredenin, S. B.
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
Biomedical and Life Sciences
Biomedicine
Brain-derived neurotrophic factor
Cell Biology
CELL CYCLE
Cell Cycle - drug effects
Cell growth
Cell Line, Tumor
Cell lines
CELL PROLIFERATION
Cell Proliferation - drug effects
Dipeptides - chemistry
Dipeptides - pharmacology
DRUGS
Flow Cytometry
Glycine
HEK293 Cells
Humans
Internal Medicine
Ki-67 Antigen - metabolism
Laboratory Medicine
Nerve growth factor
Neuroprotection
Neuroprotective Agents - pharmacology
Pathology
Peptides - chemistry
Peptides - pharmacology
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Summary:Effects of Noopept ( N -phenylacetyl- L -prolylglycine ethyl ester) on the relative level of proliferation marker Ki-67 and cell cycle parameters were studied in HEK293 and SH-SY5Y cell lines. The previously established multifactorial mechanism of action of the drug includes enhancement of neurotrophin NGF and BDNF expression and increase in HIF-1 activity. The possible mitogenic action of Noopept was estimated by its effect on cell proliferation. Noopept did not affect cell distribution over G1, S, G2 cell cycle phases and the relative level of proliferation marker Ki-67 in the cell lines under study. These data suggest that Noopept does not stimulate cell growth.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-019-04373-8