Low expression level of HMBOX1 in high-grade serous ovarian cancer accelerates cell proliferation by inhibiting cell apoptosis

Homeobox-containing 1 (HMBOX1) has been described as a transcription factor involved in the occurrence of some tumors, but its roles in ovarian cancer have never been reported. Here we aimed to investigate the roles of HMBOX1 on high-grade serous ovarian carcinoma (HGSOC). In this present study, HMB...

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Published in:Biochemical and biophysical research communications 2018-06, Vol.501 (2), p.380-386
Main Authors: Yu, Yun-Liang, Diao, Nan-Nan, Li, Yu-Zheng, Meng, Xiao-Hui, Jiao, Wen-Lin, Feng, Jin-Bo, Liu, Zhen-Ping, Lu, Nan
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
APOPTOSIS
CARCINOMAS
CELL PROLIFERATION
High-grade serous ovarian cancer
HMBOX1
OVARIES
Proliferation
TRANSCRIPTION FACTORS
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Summary:Homeobox-containing 1 (HMBOX1) has been described as a transcription factor involved in the occurrence of some tumors, but its roles in ovarian cancer have never been reported. Here we aimed to investigate the roles of HMBOX1 on high-grade serous ovarian carcinoma (HGSOC). In this present study, HMBOX1 expression was decreased in HGSOC tissues and ovarian cancer cell lines (HO8910 and A2780) compared with ovarian surface epithelial tissues or normal human ovarian surface epithelial cell line (HOSEpiC). The cell proliferation of HOSEpiC was weaker than ovarian cancer cell lines. By altering the expression of HMBOX1 in A2780 and HOSEpiC, we demonstrated that HMBOX1 inhibited the cell proliferation and promoted the cell apoptosis. Furthermore, our study revealed that HMBOX1 downregulated the expression of anti-apoptotic proteins (Bcl-2, Bcl-xL), raised the expression of pro-apoptotic-regulated proteins (Bad, Bax), apoptotic executionior (Caspase3), and P53. In conclusion, HMBOX1 played important roles in occurrence of HGSOC through regulation of proliferation and apoptosis, which implied that HMBOX1 might serve as a new therapeutic target for HGSOC. •HMBOX1 was significantly downregulated in HGSOC tissues and ovarian cancer cell lines.•There was a negative correlation between the expression of HMBOX1 and cell proliferation of ovarian cancer cell lines.•HMBOX1 inhibited the cell proliferation and promoted the cell apoptosis.•HMBOX1 downregulated the expression of Bcl-2, Bcl-xL and upregulated that of Bad, Bax and Caspase3.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2018.04.203