LncRNA HAND2-AS1 sponging miR-1275 suppresses colorectal cancer progression by upregulating KLF14

Long noncoding RNAs (lncRNAs) represent a novel type of noncoding RNAs of over 200 nucleotides, characterized by no or limited protein-coding potential. Although the function of lncRNAs attracts increasing attention recently, the relationship between lncRNA and colorectal cancer (CRC) remains furthe...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2018-09, Vol.503 (3), p.1848-1853
Main Authors: Zhou, Jianwei, Lin, Jiejun, Zhang, Hui, Zhu, Fangchao, Xie, Raoying
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
Colorectal cancer
HAND2-AS1
Invasion
KLF14
miR-1275
NEOPLASMS
NUCLEOTIDES
PORIFERA
Proliferation
PROTEINS
RNA
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Summary:Long noncoding RNAs (lncRNAs) represent a novel type of noncoding RNAs of over 200 nucleotides, characterized by no or limited protein-coding potential. Although the function of lncRNAs attracts increasing attention recently, the relationship between lncRNA and colorectal cancer (CRC) remains further investigation. In our study, we found that lncRNA HAND2-AS1 was markedly downregulated in CRC tissues. And its expression level was negatively correlated with metastasis and advanced stage in CRC patients. Furthermore, we showed that HAND2-AS1 low expression predicted poor prognosis. Functionally, we found that overexpression of HAND2-AS1 obviously attenuated the proliferation and invasion of CRC cells. Ectopic expression of HAND2-AS1 also inhibited tumor propagation in vivo. In mechanism, HAND2-AS1 served as a sponge of miR-1275 which targeted KLF14. Through facilitating KLF14 expression, HAND2-AS1 suppressed CRC progression. In conclusion, our study demonstrated that HAND2-AS1 exerts a suppressive role in CRC by sponging miR-1275 and modulating KLF14 expression.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2018.07.125