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Circular RNA circMAN2B2 facilitates lung cancer cell proliferation and invasion via miR-1275/FOXK1 axis
Lung cancer remains a leading cause of cancer-related deaths worldwide. In the past years, increasing reports indicate that circular RNAs (circRNAs) exert a great important role in human cancers, including lung cancer. However, the knowledge about circRNA in lung cancer remains very little so far. I...
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Published in: | Biochemical and biophysical research communications 2018-04, Vol.498 (4), p.1009-1015 |
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container_title | Biochemical and biophysical research communications |
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creator | Ma, Xuemei Yang, Xiaodong Bao, Wenhua Li, Shumin Liang, Shanshan Sun, Yunhui Zhao, Yunwei Wang, Jing Zhao, Chenxu |
description | Lung cancer remains a leading cause of cancer-related deaths worldwide. In the past years, increasing reports indicate that circular RNAs (circRNAs) exert a great important role in human cancers, including lung cancer. However, the knowledge about circRNA in lung cancer remains very little so far. In the present study, we screened out a highly expressed novel circRNA named circMAN2B2 in lung cancer tissues. We investigated the function of circMAN2B2 and found that circMAN2B2 knockdown significantly inhibited cell proliferation and invasion in both H1299 and A549 lung cancer cells. Mechanistically, we found that circMAN2B2 could sponge miR-1275 to inhibit its level. Through a series of functional experiments, we dissected the role of miR-1275 in lung cancer and proved the anti-tumor role of miR-1275. Furthermore, we found that miR-1275 exerted its role in lung cancer by regulating FOXK1 expression. In addition, we demonstrated that restoration of FOXK1 could rescue circMAN2B2 knockdown-induced repression of cell proliferation and invasion. Taken together, our study demonstrated that circMAN2B2 acts as an oncogenic role in lung cancer through promoting FOXK1 expression by sponging miR-1275.
•CircMAN2B2 knockdown suppresses lung cancer cell proliferation and invasion.•CircMAN2B2 sponges and represses miR-1275 expression in lung cancer.•miR-1275 exerts its role by regulation of FOXK1 expression in lung cancer.•CircMAN2B2 promotes lung cancer cell proliferation an invasion via circMAN2B2/miR-1275/FOXK1 signaling. |
doi_str_mv | 10.1016/j.bbrc.2018.03.105 |
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•CircMAN2B2 knockdown suppresses lung cancer cell proliferation and invasion.•CircMAN2B2 sponges and represses miR-1275 expression in lung cancer.•miR-1275 exerts its role by regulation of FOXK1 expression in lung cancer.•CircMAN2B2 promotes lung cancer cell proliferation an invasion via circMAN2B2/miR-1275/FOXK1 signaling.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2018.03.105</identifier><identifier>PMID: 29550475</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>60 APPLIED LIFE SCIENCES ; A549 Cells ; Cell Line, Tumor ; Cell Movement - genetics ; CELL PROLIFERATION ; Cell Proliferation - genetics ; CircMAN2B2 ; Forkhead Transcription Factors - metabolism ; Forkhead Transcription Factors - physiology ; FOXK1 ; HUMAN POPULATIONS ; Humans ; Invasion ; Lung cancer ; Lung Neoplasms - pathology ; LUNGS ; MicroRNAs - antagonists & inhibitors ; MicroRNAs - metabolism ; MicroRNAs - physiology ; miR-1275 ; NEOPLASMS ; PORIFERA ; Proliferation ; RNA ; RNA - physiology</subject><ispartof>Biochemical and biophysical research communications, 2018-04, Vol.498 (4), p.1009-1015</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-3981cb17b96683bf35f33a78680ecd870bd62200d69da08927e90d77be09534a3</citedby><cites>FETCH-LOGICAL-c384t-3981cb17b96683bf35f33a78680ecd870bd62200d69da08927e90d77be09534a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29550475$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/23137216$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Xuemei</creatorcontrib><creatorcontrib>Yang, Xiaodong</creatorcontrib><creatorcontrib>Bao, Wenhua</creatorcontrib><creatorcontrib>Li, Shumin</creatorcontrib><creatorcontrib>Liang, Shanshan</creatorcontrib><creatorcontrib>Sun, Yunhui</creatorcontrib><creatorcontrib>Zhao, Yunwei</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Zhao, Chenxu</creatorcontrib><title>Circular RNA circMAN2B2 facilitates lung cancer cell proliferation and invasion via miR-1275/FOXK1 axis</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Lung cancer remains a leading cause of cancer-related deaths worldwide. In the past years, increasing reports indicate that circular RNAs (circRNAs) exert a great important role in human cancers, including lung cancer. However, the knowledge about circRNA in lung cancer remains very little so far. In the present study, we screened out a highly expressed novel circRNA named circMAN2B2 in lung cancer tissues. We investigated the function of circMAN2B2 and found that circMAN2B2 knockdown significantly inhibited cell proliferation and invasion in both H1299 and A549 lung cancer cells. Mechanistically, we found that circMAN2B2 could sponge miR-1275 to inhibit its level. Through a series of functional experiments, we dissected the role of miR-1275 in lung cancer and proved the anti-tumor role of miR-1275. Furthermore, we found that miR-1275 exerted its role in lung cancer by regulating FOXK1 expression. In addition, we demonstrated that restoration of FOXK1 could rescue circMAN2B2 knockdown-induced repression of cell proliferation and invasion. Taken together, our study demonstrated that circMAN2B2 acts as an oncogenic role in lung cancer through promoting FOXK1 expression by sponging miR-1275.
•CircMAN2B2 knockdown suppresses lung cancer cell proliferation and invasion.•CircMAN2B2 sponges and represses miR-1275 expression in lung cancer.•miR-1275 exerts its role by regulation of FOXK1 expression in lung cancer.•CircMAN2B2 promotes lung cancer cell proliferation an invasion via circMAN2B2/miR-1275/FOXK1 signaling.</description><subject>60 APPLIED LIFE SCIENCES</subject><subject>A549 Cells</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement - genetics</subject><subject>CELL PROLIFERATION</subject><subject>Cell Proliferation - genetics</subject><subject>CircMAN2B2</subject><subject>Forkhead Transcription Factors - metabolism</subject><subject>Forkhead Transcription Factors - physiology</subject><subject>FOXK1</subject><subject>HUMAN POPULATIONS</subject><subject>Humans</subject><subject>Invasion</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - pathology</subject><subject>LUNGS</subject><subject>MicroRNAs - antagonists & inhibitors</subject><subject>MicroRNAs - metabolism</subject><subject>MicroRNAs - physiology</subject><subject>miR-1275</subject><subject>NEOPLASMS</subject><subject>PORIFERA</subject><subject>Proliferation</subject><subject>RNA</subject><subject>RNA - physiology</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kU1r3DAQhkVoSTZp_kAORdBLL96MJOsLetkuzQdNEwgt5CZkSU61eO1Espfm31dm0xx7GmZ43peZdxA6I7AkQMT5Ztk0yS0pELUEVmb8AC0IaKgogfodWgCAqKgmD0foOOcNACG10IfoiGrOoZZ8gR7XMbmpswnf366wK82P1S39SnFrXeziaMeQcTf1j9jZ3oWEXeg6_JSGLrYh2TEOPba9x7Hf2Tw3u2jxNt5XhEp-fnH38J1g-yfmD-h9a7scTl_rCfp18e3n-qq6ubu8Xq9uKsdUPVZMK-IaIhsthGJNy3jLmJVKKAjOKwmNF5QCeKG9BaWpDBq8lE0AzVlt2Qn6tPcd8hhNdnEM7rcb-j640VBGmKREFOrzniqHPE8hj2Yb83yZ7cMwZVMi5TUBUeuC0j3q0pBzCq15SnFr04shYOY3mI2Z3zBrlAFWZryIPr76T802-DfJv9wL8GUPhJLFLoY0rxpKwD6meVM_xP_5_wUEw5Wh</recordid><startdate>20180415</startdate><enddate>20180415</enddate><creator>Ma, Xuemei</creator><creator>Yang, Xiaodong</creator><creator>Bao, Wenhua</creator><creator>Li, Shumin</creator><creator>Liang, Shanshan</creator><creator>Sun, Yunhui</creator><creator>Zhao, Yunwei</creator><creator>Wang, Jing</creator><creator>Zhao, Chenxu</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>20180415</creationdate><title>Circular RNA circMAN2B2 facilitates lung cancer cell proliferation and invasion via miR-1275/FOXK1 axis</title><author>Ma, Xuemei ; Yang, Xiaodong ; Bao, Wenhua ; Li, Shumin ; Liang, Shanshan ; Sun, Yunhui ; Zhao, Yunwei ; Wang, Jing ; Zhao, Chenxu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-3981cb17b96683bf35f33a78680ecd870bd62200d69da08927e90d77be09534a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>60 APPLIED LIFE SCIENCES</topic><topic>A549 Cells</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement - genetics</topic><topic>CELL PROLIFERATION</topic><topic>Cell Proliferation - genetics</topic><topic>CircMAN2B2</topic><topic>Forkhead Transcription Factors - metabolism</topic><topic>Forkhead Transcription Factors - physiology</topic><topic>FOXK1</topic><topic>HUMAN POPULATIONS</topic><topic>Humans</topic><topic>Invasion</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - pathology</topic><topic>LUNGS</topic><topic>MicroRNAs - antagonists & inhibitors</topic><topic>MicroRNAs - metabolism</topic><topic>MicroRNAs - physiology</topic><topic>miR-1275</topic><topic>NEOPLASMS</topic><topic>PORIFERA</topic><topic>Proliferation</topic><topic>RNA</topic><topic>RNA - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Xuemei</creatorcontrib><creatorcontrib>Yang, Xiaodong</creatorcontrib><creatorcontrib>Bao, Wenhua</creatorcontrib><creatorcontrib>Li, Shumin</creatorcontrib><creatorcontrib>Liang, Shanshan</creatorcontrib><creatorcontrib>Sun, Yunhui</creatorcontrib><creatorcontrib>Zhao, Yunwei</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Zhao, Chenxu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Xuemei</au><au>Yang, Xiaodong</au><au>Bao, Wenhua</au><au>Li, Shumin</au><au>Liang, Shanshan</au><au>Sun, Yunhui</au><au>Zhao, Yunwei</au><au>Wang, Jing</au><au>Zhao, Chenxu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circular RNA circMAN2B2 facilitates lung cancer cell proliferation and invasion via miR-1275/FOXK1 axis</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2018-04-15</date><risdate>2018</risdate><volume>498</volume><issue>4</issue><spage>1009</spage><epage>1015</epage><pages>1009-1015</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Lung cancer remains a leading cause of cancer-related deaths worldwide. In the past years, increasing reports indicate that circular RNAs (circRNAs) exert a great important role in human cancers, including lung cancer. However, the knowledge about circRNA in lung cancer remains very little so far. In the present study, we screened out a highly expressed novel circRNA named circMAN2B2 in lung cancer tissues. We investigated the function of circMAN2B2 and found that circMAN2B2 knockdown significantly inhibited cell proliferation and invasion in both H1299 and A549 lung cancer cells. Mechanistically, we found that circMAN2B2 could sponge miR-1275 to inhibit its level. Through a series of functional experiments, we dissected the role of miR-1275 in lung cancer and proved the anti-tumor role of miR-1275. Furthermore, we found that miR-1275 exerted its role in lung cancer by regulating FOXK1 expression. In addition, we demonstrated that restoration of FOXK1 could rescue circMAN2B2 knockdown-induced repression of cell proliferation and invasion. Taken together, our study demonstrated that circMAN2B2 acts as an oncogenic role in lung cancer through promoting FOXK1 expression by sponging miR-1275.
•CircMAN2B2 knockdown suppresses lung cancer cell proliferation and invasion.•CircMAN2B2 sponges and represses miR-1275 expression in lung cancer.•miR-1275 exerts its role by regulation of FOXK1 expression in lung cancer.•CircMAN2B2 promotes lung cancer cell proliferation an invasion via circMAN2B2/miR-1275/FOXK1 signaling.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29550475</pmid><doi>10.1016/j.bbrc.2018.03.105</doi><tpages>7</tpages></addata></record> |
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subjects | 60 APPLIED LIFE SCIENCES A549 Cells Cell Line, Tumor Cell Movement - genetics CELL PROLIFERATION Cell Proliferation - genetics CircMAN2B2 Forkhead Transcription Factors - metabolism Forkhead Transcription Factors - physiology FOXK1 HUMAN POPULATIONS Humans Invasion Lung cancer Lung Neoplasms - pathology LUNGS MicroRNAs - antagonists & inhibitors MicroRNAs - metabolism MicroRNAs - physiology miR-1275 NEOPLASMS PORIFERA Proliferation RNA RNA - physiology |
title | Circular RNA circMAN2B2 facilitates lung cancer cell proliferation and invasion via miR-1275/FOXK1 axis |
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