Research progress on the mechanism of ferroptosis and its clinical application

Ferroptosis is a mode of cell death dependent on iron ions, which is mainly induced by the decrease of the biological activity of glutathione peroxidase or the accumulation of lipid peroxidation and reactive oxygen species (ROS). It is significantly different from autophagy and other forms of cell d...

Full description

Saved in:
Bibliographic Details
Published in:Experimental cell research 2021-12, Vol.409 (2), p.112932, Article 112932
Main Authors: Xia, Jiarui, Si, Huifang, Yao, Wu, Li, Chao, Yang, Guo, Tian, Yangyang, Hao, Changfu
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
Animals
APOPTOSIS
Autophagy
BIOCHEMISTRY
Clinical application
Diseases
Ferroptosis
GLUTATHIONE
Humans
Inducer
Inhibitor
Iron - metabolism
IRON IONS
LIPIDS
Mechanism
MORPHOLOGY
NEOPLASMS
Neoplasms - metabolism
Neoplasms - pathology
NERVOUS SYSTEM DISEASES
Nervous System Diseases - metabolism
Nervous System Diseases - pathology
PEROXIDASES
Reactive Oxygen Species - metabolism
REVIEWS
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ferroptosis is a mode of cell death dependent on iron ions, which is mainly induced by the decrease of the biological activity of glutathione peroxidase or the accumulation of lipid peroxidation and reactive oxygen species (ROS). It is significantly different from autophagy and other forms of cell death in terms of cell morphology and biochemistry. The exact mechanisms of ferroptosis are not clear. More and more studies have shown that various tumor diseases and nervous system diseases are closely related to ferroptosis. The occurrence and development of related diseases can be tolerated by stimulating or inhibiting the occurrence of ferroptosis. Therefore, ferroptosis has occupied a very important position in recent years. This article reviews the discovery process, characteristics, mechanisms, inducers, inhibitors of ferroptosis and its related clinical applications to lay a foundation for follow-up researchers to study ferroptosis and provide some reference value.
ISSN:0014-4827
1090-2422
DOI:10.1016/j.yexcr.2021.112932