Are grid cells used for navigation? On local metrics, subjective spaces, and black holes

• Published in: Neuron (Cambridge, Mass.) Mass.), 2023-06, Vol.111 (12), p.1858-1875
• Main Authors: Ginosar, Gily, Aljadeff, Johnatan, Las, Liora, Derdikman, Dori, Ulanovsky, Nachum
• Format: Article
• Language: English
• Subjects: BASIC BIOLOGICAL SCIENCES; Neurosciences & Neurology
• ISSN: 0896-6273; 1097-4199
• DOI: 10.1016/j.neuron.2023.03.027

The symmetric, lattice-like spatial pattern of grid-cell activity is thought to provide a neuronal global metric for space. This view is compatible with grid cells recorded in empty boxes but inconsistent with data from more naturalistic settings. We review evidence arguing against the global-metric notion, including the distortion and disintegration of the grid pattern in complex and three-dimensional environments. We argue that deviations from lattice symmetry are key for understanding grid-cell function. We propose three possible functions for grid cells, which treat real-world grid distortions as a feature rather than a bug. First, grid cells may constitute a local metric for proximal space rather than a global metric for all space. Second, grid cells could form a metric for subjective action-relevant space rather than physical space. Third, distortions may represent salient locations. Finally, we discuss mechanisms that can underlie these functions. These ideas may transform our thinking about grid cells. Ginosar et al. review recent evidence from rodents and bats, arguing against the classic hypothesis that grid cells provide a global metric for space. They propose three alternative hypotheses, with transformative implications for the function of grid cells.