ENHANCED SURVIVAL OF SKIN HOMOGRAFTS IN MICE WITH A BACTERIAL INFECTION

During an unrelated experiment, A-strain mice injected with 0.5 x 10⁹ C³H/He splenic cells were given skin homografts from the original spleen donor. In 4 of the 14 grafted animals prolongation of the homograft survival coincides with the presence of a large, chronic, intraperitoneal abscess caused...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1964-03, Vol.114 (1), p.487-495
Main Authors: Iossifides, I. A., Gutzait, L., Brand, M., Tocantins, L. M.
Format: Article
Language:English
Subjects:
ANIMAL CELLS
ANTIGENS
BACTERIA
BIOLOGY
BIOLOGY AND MEDICINE
IMMUNITY
INFECTIONS
INTESTINE
MICE
PHYSIOLOGY
SKIN
SPLEEN
SURGERY
SUSPENSIONS
TESTING
TISSUES
TRANSPLANTS
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Summary:During an unrelated experiment, A-strain mice injected with 0.5 x 10⁹ C³H/He splenic cells were given skin homografts from the original spleen donor. In 4 of the 14 grafted animals prolongation of the homograft survival coincides with the presence of a large, chronic, intraperitoneal abscess caused by a Corynebacterium species. The observation suggested the possibility of a relation between bacterial infection and the homograft survival. In attempts to investigate this possibility A mice were inoculated intraperitoneally with the same organism. In only 9 of 67 infected animals a large abscess was formed; these nine mice showed an average of five days' increase in the mean homograft survival-time. Splenectomies did not alter the results. The number of experiments is small for statistical analysis but an indication is offered that within the anlmal an interdependency and a mutual influence may exist between immunologic reactions against bacterial and against tissue antigens. (auth)
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1964.tb53601.x