ENHANCED SURVIVAL OF SKIN HOMOGRAFTS IN MICE WITH A BACTERIAL INFECTION

During an unrelated experiment, A-strain mice injected with 0.5 x 10⁹ C³H/He splenic cells were given skin homografts from the original spleen donor. In 4 of the 14 grafted animals prolongation of the homograft survival coincides with the presence of a large, chronic, intraperitoneal abscess caused...

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Published in:Annals of the New York Academy of Sciences 1964-03, Vol.114 (1), p.487-495
Main Authors: Iossifides, I. A., Gutzait, L., Brand, M., Tocantins, L. M.
Format: Article
Language:English
Subjects:
ANIMAL CELLS
ANTIGENS
BACTERIA
BIOLOGY
BIOLOGY AND MEDICINE
IMMUNITY
INFECTIONS
INTESTINE
MICE
PHYSIOLOGY
SKIN
SPLEEN
SURGERY
SUSPENSIONS
TESTING
TISSUES
TRANSPLANTS
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cited_by cdi_FETCH-LOGICAL-c2997-fc907daae34278dfb0cf7067f6b7074e3bcedb508490b401c89bde123ac775873
cites cdi_FETCH-LOGICAL-c2997-fc907daae34278dfb0cf7067f6b7074e3bcedb508490b401c89bde123ac775873
container_end_page 495
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container_title Annals of the New York Academy of Sciences
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creator Iossifides, I. A.
Gutzait, L.
Brand, M.
Tocantins, L. M.
description During an unrelated experiment, A-strain mice injected with 0.5 x 10⁹ C³H/He splenic cells were given skin homografts from the original spleen donor. In 4 of the 14 grafted animals prolongation of the homograft survival coincides with the presence of a large, chronic, intraperitoneal abscess caused by a Corynebacterium species. The observation suggested the possibility of a relation between bacterial infection and the homograft survival. In attempts to investigate this possibility A mice were inoculated intraperitoneally with the same organism. In only 9 of 67 infected animals a large abscess was formed; these nine mice showed an average of five days' increase in the mean homograft survival-time. Splenectomies did not alter the results. The number of experiments is small for statistical analysis but an indication is offered that within the anlmal an interdependency and a mutual influence may exist between immunologic reactions against bacterial and against tissue antigens. (auth)
doi_str_mv 10.1111/j.1749-6632.1964.tb53601.x
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identifier ISSN: 0077-8923
ispartof Annals of the New York Academy of Sciences, 1964-03, Vol.114 (1), p.487-495
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1749-6632
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source Wiley-Blackwell Journals (Backfile Content)
subjects ANIMAL CELLS
ANTIGENS
BACTERIA
BIOLOGY
BIOLOGY AND MEDICINE
IMMUNITY
INFECTIONS
INTESTINE
MICE
PHYSIOLOGY
SKIN
SPLEEN
SURGERY
SUSPENSIONS
TESTING
TISSUES
TRANSPLANTS
title ENHANCED SURVIVAL OF SKIN HOMOGRAFTS IN MICE WITH A BACTERIAL INFECTION
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