Vibrational Imaging with High Sensitivity via Epidetected Coherent Anti-Stokes Raman Scattering Microscopy

We demonstrate theoretically and experimentally a novel epidetection scheme for coherent anti-Stokes Raman scattering (CARS) microscopy that significantly improves the detection sensitivity. Calculations show that epidetected CARS (E-CARS) signals are present for scatterers smaller than the waveleng...

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Bibliographic Details
Published in:Physical review letters 2001-07, Vol.87 (2), Article 023901
Main Authors: Volkmer, Andreas, Cheng, Ji-Xin, Sunney Xie, X.
Format: Article
Language:English
Subjects:
CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS
DETECTION
MICROSCOPY
SCATTERING
SENSITIVITY
SOLVENTS
WATER
WAVELENGTHS
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Summary:We demonstrate theoretically and experimentally a novel epidetection scheme for coherent anti-Stokes Raman scattering (CARS) microscopy that significantly improves the detection sensitivity. Calculations show that epidetected CARS (E-CARS) signals are present for scatterers smaller than the wavelength of light, whereas the large background signals from the surrounding bulk solvent are suppressed by destructive interference. E-CARS microscopy is capable of revealing small intracellular features that are otherwise buried by the strong water CARS signal.
ISSN:0031-9007
1079-7114
DOI:10.1103/PhysRevLett.87.023901