X-rays Affect the Incorporation of 5-Iododeoxyuridine into Deoxyribonucleic Acid

When labeled with iodine-131, 5-iododeoxyuridine, an analogue of thymidine, is useful in estimating the effect of x-radiation on deoxyribonucleic acid metabolism. Although this compound is readily incorporated into deoxyribonucleic acid in the absence of ionizing radiation, we find that whole-body e...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1961-04, Vol.133 (3458), p.1074-1075
Main Authors: Gitlin, David, Commerford, S. Lewis, Amsterdam, Ezra, Hughes, Walter L.
Format: Article
Language:English
Subjects:
Biochemical Phenomena
DNA
DNA - metabolism
Idoxuridine
Iodides
Irradiation
Nucleosides - metabolism
Nucleotides - metabolism
Old Medline
Radiation dosage
Radiation Effects
Radiation, Ionizing
Radioactive decay
Radioisotopes
RADIOLOGY AND NUCLEAR MEDICINE
Spleen
Stem cells
X-Rays
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Summary:When labeled with iodine-131, 5-iododeoxyuridine, an analogue of thymidine, is useful in estimating the effect of x-radiation on deoxyribonucleic acid metabolism. Although this compound is readily incorporated into deoxyribonucleic acid in the absence of ionizing radiation, we find that whole-body exposure to as little as 10 r will significantly inhibit its incorporation.
ISSN:0036-8075
1095-9203
1095-9203
DOI:10.1126/science.133.3458.1074