X-rays Affect the Incorporation of 5-Iododeoxyuridine into Deoxyribonucleic Acid

When labeled with iodine-131, 5-iododeoxyuridine, an analogue of thymidine, is useful in estimating the effect of x-radiation on deoxyribonucleic acid metabolism. Although this compound is readily incorporated into deoxyribonucleic acid in the absence of ionizing radiation, we find that whole-body e...

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Published in:Science (American Association for the Advancement of Science) 1961-04, Vol.133 (3458), p.1074-1075
Main Authors: Gitlin, David, Commerford, S. Lewis, Amsterdam, Ezra, Hughes, Walter L.
Format: Article
Language:English
Subjects:
Biochemical Phenomena
DNA
DNA - metabolism
Idoxuridine
Iodides
Irradiation
Nucleosides - metabolism
Nucleotides - metabolism
Old Medline
Radiation dosage
Radiation Effects
Radiation, Ionizing
Radioactive decay
Radioisotopes
RADIOLOGY AND NUCLEAR MEDICINE
Spleen
Stem cells
X-Rays
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cited_by cdi_FETCH-LOGICAL-c386t-85961b316f167f71b2db7f64affbab7a0051718d98c949a2b4fa087e2ae4d8863
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container_title Science (American Association for the Advancement of Science)
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creator Gitlin, David
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description When labeled with iodine-131, 5-iododeoxyuridine, an analogue of thymidine, is useful in estimating the effect of x-radiation on deoxyribonucleic acid metabolism. Although this compound is readily incorporated into deoxyribonucleic acid in the absence of ionizing radiation, we find that whole-body exposure to as little as 10 r will significantly inhibit its incorporation.
doi_str_mv 10.1126/science.133.3458.1074
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identifier ISSN: 0036-8075
ispartof Science (American Association for the Advancement of Science), 1961-04, Vol.133 (3458), p.1074-1075
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source Science Online_科学在线; JSTOR Archival Journals
subjects Biochemical Phenomena
DNA
DNA - metabolism
Idoxuridine
Iodides
Irradiation
Nucleosides - metabolism
Nucleotides - metabolism
Old Medline
Radiation dosage
Radiation Effects
Radiation, Ionizing
Radioactive decay
Radioisotopes
RADIOLOGY AND NUCLEAR MEDICINE
Spleen
Stem cells
X-Rays
title X-rays Affect the Incorporation of 5-Iododeoxyuridine into Deoxyribonucleic Acid
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