The Effect of Whole-Body X-Irradiation on the Langerhans' Islets in the Rat

The sublethal total-body x irradiation of the rat causes an increase in the beta / alpha -cell ratio of the insular tissue 24 hours after irradiation. The ratio decreases gradually until nearly the thirtieth day, and after that period it rises again. The first increase could be ascribed to the forma...

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Bibliographic Details
Published in:Radiation research 1960-07, Vol.13 (1), p.18-24
Main Authors: Allegretti, Nikša, Matošić, Miloje, Šestan, Neda, Devčić, Magda, Rabadjija, Luka, Šlamberger, Suzana
Format: Article
Language:English
Subjects:
ANIMAL CELLS
BIOLOGY AND MEDICINE
BODY
CYTOLOGY
GLANDS
Glucose tolerance test
Guinea pigs
Histology
IRRADIATION
ISING MODEL
LETHAL DOSE
MITOSIS
PANCREAS
RADIATION EFFECTS
RATS
Regression coefficients
VARIATIONS
X RADIATION
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Summary:The sublethal total-body x irradiation of the rat causes an increase in the beta / alpha -cell ratio of the insular tissue 24 hours after irradiation. The ratio decreases gradually until nearly the thirtieth day, and after that period it rises again. The first increase could be ascribed to the formation of new islets containing mostly beta -cells; the last increase, however, could be ascribed to the growth of the islets by formation of beta -cells.
ISSN:0033-7587
1938-5404
DOI:10.2307/3570869