Reduction of Radiostrontium Uptake in the Rat

• Published in: Radiation research 1969-05, Vol.38 (2), p.340-348
• Main Authors: Friedland, Joan A., Brdlik, Otto B., Methfessel, Alfred H., Spencer, Herta
• Format: Article
• Language: English
• Subjects: Aluminum; ALUMINUM PHOSPHATES; ALUMINUM PHOSPHATES/effects of colloidal, on strontium-85 uptake by rats; Animals; Antacids - administration & dosage; Antacids - pharmacology; BLOOD; BLOOD/strontium-85 uptake by, in rats, effects of treatment with aluminum phosphate colloids on; Bone and Bones - metabolism; BONES; BONES/strontium-85 uptake by, in rats, effects of treatment with aluminum phosphate colloids on; Calcium; COLLOIDS; Control groups; DRUGS; Femur - analysis; Gastrointestinal tract; Gels; Intestinal Absorption - drug effects; INTESTINE; INTESTINES/strontium-85 uptake by, in rats, effects of treatment with aluminum phosphate colloids on; Intubation; Intubation, Gastrointestinal; Isotopes; Male; METABOLISM; N28130 -Life Sciences-Biochemistry, Physiology, & Molecular Biology-Metabolism, Physiology & Toxicology; N28510 -Life Sciences-Medicine-Protective Substances; Phosphates; RATS; RATS/strontium-85 uptake by blood, bones, and intestine in, effects of treatment with aluminum phosphate colloids on; Space life sciences; Strontium; STRONTIUM 85; Strontium Isotopes - blood; Strontium Isotopes - metabolism; STRONTIUM ISOTOPES Sr-85/uptake by blood, bones, and intestine following gastric administration in rats, effects of treatment with aluminum phosphate colloids on; TESTING
• ISSN: 0033-7587; 1938-5404
• DOI: 10.2307/3572776

Ten experiments were performed in rats to study the effect of aluminum phosphate gel on the uptake of radiostrontium in bone. Aluminum phosphate gel was given by gastric intubation, immediately prior to, immediately after, and at 10 minutes, 30 minutes, and 1 hour after the oral administration of^{85}{\rm SrCl}{}_{2}$. The uptake of^{85}{\rm Sr}$in bone was determined in groups of rats sacrificed at 1 hour and at 24 hours following the oral^{85}{\rm Sr}$administration. The^{85}{\rm Sr}$blood levels and the^{85}{\rm Sr}$content in the gastrointestinal tract were determined in addition to the^{85}{\rm Sr}$bone uptake in groups of rats sacrificed at 1 hour following the administration of the radioisotope. In the rats sacrified at 1 hour, aluminum phosphate gel, given either immediately prior to or immediately after the oral dose of^{85}{\rm Sr}$, decreased the^{85}{\rm Sr}$blood level by an average of 85% and the bone uptake by an average of 88%. At 10 minutes,^{85}{\rm Sr}$uptake in bone was decreased by an average of 62%, while at 1/2 hour the decrease averaged only 35%. When aluminum phosphate gel was given at the same time intervals to rats sacrificed at 24 hours, the results were similar. However, when aluminum phosphate gel was given at 1 hour after the oral dose of^{85}{\rm Sr}$, to rats sacrified at 24 hours, the uptake of the radioisotope in bone was unchanged. The decrease in^{85}{\rm Sr}$concentration in blood and bone was associated with a corresponding increase of the^{85}{\rm Sr}$content in the gastrointestinal tract. These studies show that aluminum phosphate gel is effective in decreasing the uptake of^{85}{\rm Sr}$in bone as a result of decreased absorption of radiostrontium.