Influence of Pre- and Post-X-Irradiation Zymosan Administration on Reticuloendothelial Function

Phagocytic activity, evaluated by the intravascular removal rate of colloidal carbon, was determined in mice injected with the reticuloendothelial (RE) stimulating agent, trypsinized zymosan, either prior to or immediately after exposure to 1000 r. Half-times (t/2), global phagocytic activity, corre...

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Bibliographic Details
Published in:Radiation research 1962-04, Vol.16 (4), p.546-554
Main Authors: Wooles, W. R., Elko, E. E., Di Luzio, N. R.
Format: Article
Language:English
Subjects:
ANIMAL CELLS
BLOOD VESSELS
CARBON
COLLOIDS
ENZYMES
Hyperplasia
Intravenous injections
Ionizing radiation
Kupffer cells
LIFETIME
LIVER
MICE
Mononuclear Phagocyte System - radiation effects
Old Medline
Phagocytes
PHAGOCYTOSIS
Polysaccharides - pharmacology
Radiation dosage
RADIATION DOSES
RADIATION PROTECTION
Radiation tolerance
RADIOLOGY AND NUCLEAR MEDICINE
SPLEEN
WEIGHT
X RADIATION
ZYMOSAN
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Summary:Phagocytic activity, evaluated by the intravascular removal rate of colloidal carbon, was determined in mice injected with the reticuloendothelial (RE) stimulating agent, trypsinized zymosan, either prior to or immediately after exposure to 1000 r. Half-times (t/2), global phagocytic activity, corrected phagocytic activity, and weight changes of liver and spleen were determined at frequent postirradiation intervals. The hyperphagocytic state induced by the injection of zymosan was unaltered after radiation exposure. Phagocytic function was significantly impaired in normal mice 96 hours after exposure. In contrast, the injection of zymosan after exposure maintained normal RE function but did not induce a hyperfunctional state. Survival to various doses of x irradiation was unaltered by zymosaninduced RE stimulation.
ISSN:0033-7587
1938-5404
DOI:10.2307/3571087