Dose-response analysis of infants prenatally exposed to methyl mercury: An application of a single compartment model to single-strand hair analysis

A new method of estimating fetal exposure is used in a dose-response analysis of data from the 1971 outbreak of methyl mercury poisoning in rural Iraq. An X-ray fluorescence instrument for the measurement of single strands of human hair was employed to obtain longitudinal profiles recapitulating fet...

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Bibliographic Details
Published in:Environmental research 1989-08, Vol.49 (2), p.318-332
Main Authors: Cox, Christopher, Clarkson, Thomas W., Marsh, David O., Amin-Zaki, Laman, Tikriti, Sa'adoun, Myers, Gary G.
Format: Article
Language:English
Subjects:
550600 - Medicine
560300 - Chemicals Metabolism & Toxicology
AGE GROUPS
ASIA
Biological and medical sciences
BLE
BODY
Bread
CENTRAL NERVOUS SYSTEM
Central Nervous System - drug effects
CHEMICAL ANALYSIS
CHILDREN
CONTAMINANTES
DEVELOPING COUNTRIES
Developmental Disabilities - etiology
DOSE-RESPONSE RELATIONSHIPS
FARINE
Female
FLOURS
FONGICIDE
Food Contamination
FOOD HYGIENE
Food toxicology
FUNGICIDAS
FUNGICIDES
GESTACION
GESTATION
HAIR
Hair - analysis
HARINAS
HIGIENE DE LOS ALIMENTOS
Humans
HYGIENE DES ALIMENTS
Infant, Newborn
INFANTES
INFANTS
IRAK
IRAQ
Maternal-Fetal Exchange
Medical sciences
MERCURY COMPOUNDS
METHYLMERCURY
Methylmercury Compounds - poisoning
MIDDLE EAST
Models, Theoretical
NERVOUS SYSTEM
NONDESTRUCTIVE ANALYSIS
NOUVEAU-NE
OPTICAL PROPERTIES
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
ORGANS
POLLUANT
POLLUTANTS
PREGNANCY
PRENATAL DAYS
PRENATAL EXPOSURE
PROPIEDADES OPTICAS
PROPRIETE OPTIQUE
RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT
RADIOLOGY AND NUCLEAR MEDICINE
RISK ASSESSMENT
Risk Factors
SENSITIVITY
SKIN
Spectrometry, X-Ray Emission - methods
TOXICITY
Toxicology
TRIGO
WHEATS
X RAY FLUORESCENCE
X-RAY EMISSION ANALYSIS
X-RAY FLUORESCENCE ANALYSIS
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Summary:A new method of estimating fetal exposure is used in a dose-response analysis of data from the 1971 outbreak of methyl mercury poisoning in rural Iraq. An X-ray fluorescence instrument for the measurement of single strands of human hair was employed to obtain longitudinal profiles recapitulating fetal exposure. Logit and hockey-stick models as well as nonparametric smoothing are used to describe data on delayed development and central nervous system abnormality.
ISSN:0013-9351
1096-0953
DOI:10.1016/S0013-9351(89)80075-1