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Intramural Hemorrhage and Endothelial Changes in Atherosclerotic Coronary Artery After Repetitive Episodes of Spasm in X-ray-Irradiated Hypercholesterolemic Pigs
To assess whether coronary spasm affects the progression of atherosclerosis and results in evolution of myocardial infarction, the role of coronary spasm on the fine structure of conduit coronary arteries was studied morphologically. Göttingen miniature pigs were fed a semisynthetic diet containing...
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| Published in: | Circulation research 1989-08, Vol.65 (2), p.272-282 |
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| cited_by | cdi_FETCH-LOGICAL-c4684-eb40f5a60e28eca60000345914871f67add90c241be8b73e123a017bcc37fb4d3 |
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| container_end_page | 282 |
| container_issue | 2 |
| container_start_page | 272 |
| container_title | Circulation research |
| container_volume | 65 |
| creator | Nagasawa, Kazushige Tomoike, Hitonobu Hayashi, Yasuo Yamada, Akira Yamamoto, Torao Nakamura, Motoomi |
| description | To assess whether coronary spasm affects the progression of atherosclerosis and results in evolution of myocardial infarction, the role of coronary spasm on the fine structure of conduit coronary arteries was studied morphologically. Göttingen miniature pigs were fed a semisynthetic diet containing 2% cholesterol and 1.1% sodium cholate. One month after being on this diet, the pigs were anesthetized and the endothelium of a branch of the left coronary artery was denuded using a balloon catheter. X-ray irradiation in a dose of 1,500 rad was given twice selectively to the area denuded, after 4 and 5 months of cholesterol feeding. Five months after endothelial denudation, transient (group A) and repetitive episodes (group B) of coronary spasm were provoked by single and periodic (five times every 5 minutes) intracoronary injections of serotonin (10 μg/kg/injection), respectively. The extent of spasm by serotonin at the previously denuded site was 84±4% (n=4) and 90±5% (n=6) narrowing in groups A and B (p=NS between groups), respectively. Forty minutes after the final administration of serotonin, the left coronary artery was relaxed by nitroglycerin, and the heart was isolated and perfuse-fixed under physiological pressure. Intramural hemorrhage was noted at the spastic site in six pigs of group B but not in group A. The average percent luminal narrowing, on cross sections at the spastic site in group B, was significantly greater than in group A (56±7% vs. 23±5%,p |
| doi_str_mv | 10.1161/01.res.65.2.272 |
| format | article |
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Göttingen miniature pigs were fed a semisynthetic diet containing 2% cholesterol and 1.1% sodium cholate. One month after being on this diet, the pigs were anesthetized and the endothelium of a branch of the left coronary artery was denuded using a balloon catheter. X-ray irradiation in a dose of 1,500 rad was given twice selectively to the area denuded, after 4 and 5 months of cholesterol feeding. Five months after endothelial denudation, transient (group A) and repetitive episodes (group B) of coronary spasm were provoked by single and periodic (five times every 5 minutes) intracoronary injections of serotonin (10 μg/kg/injection), respectively. The extent of spasm by serotonin at the previously denuded site was 84±4% (n=4) and 90±5% (n=6) narrowing in groups A and B (p=NS between groups), respectively. Forty minutes after the final administration of serotonin, the left coronary artery was relaxed by nitroglycerin, and the heart was isolated and perfuse-fixed under physiological pressure. Intramural hemorrhage was noted at the spastic site in six pigs of group B but not in group A. The average percent luminal narrowing, on cross sections at the spastic site in group B, was significantly greater than in group A (56±7% vs. 23±5%,p<0.01). Scanning electron micrographs revealed that the endothelial lining was intact at the nonspastic site in both groups. In addition to the appearance of intercellular bridges at the spastic site in both groups, squeezing of endothelial cells and adhesion of white blood cells were present at the spastic site exclusively in group B. These findings are consistent with the hypothesis that repetitive spasm may have an important role in the progression of atherosclerosis and/or myocardial infarction. (Circulation Research 1989;65:272-282)</description><identifier>ISSN: 0009-7330</identifier><identifier>EISSN: 1524-4571</identifier><identifier>DOI: 10.1161/01.res.65.2.272</identifier><identifier>PMID: 2752540</identifier><identifier>CODEN: CIRUAL</identifier><language>eng</language><publisher>Hagerstown, MD: American Heart Association, Inc</publisher><subject>560152 - Radiation Effects on Animals- Animals ; AMINES ; Angiography ; ANIMAL TISSUES ; ANIMALS ; AROMATICS ; ARTERIES ; ARTERIOSCLEROSIS ; AUTONOMIC NERVOUS SYSTEM AGENTS ; AZAARENES ; AZOLES ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; BIOLOGICAL RADIATION EFFECTS ; BLOOD VESSELS ; BODY ; Cardiology. Vascular system ; CARDIOVASCULAR DISEASES ; CARDIOVASCULAR SYSTEM ; CHOLESTEROL ; CORONARIES ; Coronary Angiography ; Coronary Artery Disease - complications ; Coronary Artery Disease - pathology ; Coronary Artery Disease - physiopathology ; Coronary heart disease ; Coronary Vasospasm - complications ; Coronary Vessels - radiation effects ; DISEASES ; DOMESTIC ANIMALS ; DRUGS ; ELECTROMAGNETIC RADIATION ; ELECTRON MICROSCOPY ; ENDOTHELIUM ; Endothelium, Vascular - pathology ; Heart ; Hemodynamics ; HEMORRHAGE ; Hemorrhage - etiology ; HETEROCYCLIC COMPOUNDS ; HYDROXY COMPOUNDS ; Hypercholesterolemia - complications ; INDOLES ; IONIZING RADIATIONS ; Male ; MAMMALS ; Medical sciences ; MICROSCOPY ; Microscopy, Electron ; MINIATURE SWINE ; MYOCARDIAL INFARCTION ; NEUROREGULATORS ; ORGANIC COMPOUNDS ; ORGANIC NITROGEN COMPOUNDS ; ORGANS ; PATHOGENESIS ; PATHOLOGICAL CHANGES ; PERFUSED ORGANS ; PYRROLES ; RADIATION EFFECTS ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RADIATIONS ; RADIOPROTECTIVE SUBSTANCES ; SEROTONIN ; STEROIDS ; STEROLS ; SWINE ; Swine, Miniature ; SYMPATHOMIMETICS ; SYMPTOMS ; TISSUES ; TRYPTAMINES ; VASCULAR DISEASES ; VERTEBRATES ; X RADIATION</subject><ispartof>Circulation research, 1989-08, Vol.65 (2), p.272-282</ispartof><rights>1989 American Heart Association, Inc.</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4684-eb40f5a60e28eca60000345914871f67add90c241be8b73e123a017bcc37fb4d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7310819$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2752540$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5601548$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Nagasawa, Kazushige</creatorcontrib><creatorcontrib>Tomoike, Hitonobu</creatorcontrib><creatorcontrib>Hayashi, Yasuo</creatorcontrib><creatorcontrib>Yamada, Akira</creatorcontrib><creatorcontrib>Yamamoto, Torao</creatorcontrib><creatorcontrib>Nakamura, Motoomi</creatorcontrib><title>Intramural Hemorrhage and Endothelial Changes in Atherosclerotic Coronary Artery After Repetitive Episodes of Spasm in X-ray-Irradiated Hypercholesterolemic Pigs</title><title>Circulation research</title><addtitle>Circ Res</addtitle><description>To assess whether coronary spasm affects the progression of atherosclerosis and results in evolution of myocardial infarction, the role of coronary spasm on the fine structure of conduit coronary arteries was studied morphologically. Göttingen miniature pigs were fed a semisynthetic diet containing 2% cholesterol and 1.1% sodium cholate. One month after being on this diet, the pigs were anesthetized and the endothelium of a branch of the left coronary artery was denuded using a balloon catheter. X-ray irradiation in a dose of 1,500 rad was given twice selectively to the area denuded, after 4 and 5 months of cholesterol feeding. Five months after endothelial denudation, transient (group A) and repetitive episodes (group B) of coronary spasm were provoked by single and periodic (five times every 5 minutes) intracoronary injections of serotonin (10 μg/kg/injection), respectively. The extent of spasm by serotonin at the previously denuded site was 84±4% (n=4) and 90±5% (n=6) narrowing in groups A and B (p=NS between groups), respectively. Forty minutes after the final administration of serotonin, the left coronary artery was relaxed by nitroglycerin, and the heart was isolated and perfuse-fixed under physiological pressure. Intramural hemorrhage was noted at the spastic site in six pigs of group B but not in group A. The average percent luminal narrowing, on cross sections at the spastic site in group B, was significantly greater than in group A (56±7% vs. 23±5%,p<0.01). Scanning electron micrographs revealed that the endothelial lining was intact at the nonspastic site in both groups. In addition to the appearance of intercellular bridges at the spastic site in both groups, squeezing of endothelial cells and adhesion of white blood cells were present at the spastic site exclusively in group B. These findings are consistent with the hypothesis that repetitive spasm may have an important role in the progression of atherosclerosis and/or myocardial infarction. (Circulation Research 1989;65:272-282)</description><subject>560152 - Radiation Effects on Animals- Animals</subject><subject>AMINES</subject><subject>Angiography</subject><subject>ANIMAL TISSUES</subject><subject>ANIMALS</subject><subject>AROMATICS</subject><subject>ARTERIES</subject><subject>ARTERIOSCLEROSIS</subject><subject>AUTONOMIC NERVOUS SYSTEM AGENTS</subject><subject>AZAARENES</subject><subject>AZOLES</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL RADIATION EFFECTS</subject><subject>BLOOD VESSELS</subject><subject>BODY</subject><subject>Cardiology. Vascular system</subject><subject>CARDIOVASCULAR DISEASES</subject><subject>CARDIOVASCULAR SYSTEM</subject><subject>CHOLESTEROL</subject><subject>CORONARIES</subject><subject>Coronary Angiography</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary Artery Disease - pathology</subject><subject>Coronary Artery Disease - physiopathology</subject><subject>Coronary heart disease</subject><subject>Coronary Vasospasm - complications</subject><subject>Coronary Vessels - radiation effects</subject><subject>DISEASES</subject><subject>DOMESTIC ANIMALS</subject><subject>DRUGS</subject><subject>ELECTROMAGNETIC RADIATION</subject><subject>ELECTRON MICROSCOPY</subject><subject>ENDOTHELIUM</subject><subject>Endothelium, Vascular - pathology</subject><subject>Heart</subject><subject>Hemodynamics</subject><subject>HEMORRHAGE</subject><subject>Hemorrhage - etiology</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HYDROXY COMPOUNDS</subject><subject>Hypercholesterolemia - complications</subject><subject>INDOLES</subject><subject>IONIZING RADIATIONS</subject><subject>Male</subject><subject>MAMMALS</subject><subject>Medical sciences</subject><subject>MICROSCOPY</subject><subject>Microscopy, Electron</subject><subject>MINIATURE SWINE</subject><subject>MYOCARDIAL INFARCTION</subject><subject>NEUROREGULATORS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC NITROGEN COMPOUNDS</subject><subject>ORGANS</subject><subject>PATHOGENESIS</subject><subject>PATHOLOGICAL CHANGES</subject><subject>PERFUSED ORGANS</subject><subject>PYRROLES</subject><subject>RADIATION EFFECTS</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIATIONS</subject><subject>RADIOPROTECTIVE SUBSTANCES</subject><subject>SEROTONIN</subject><subject>STEROIDS</subject><subject>STEROLS</subject><subject>SWINE</subject><subject>Swine, Miniature</subject><subject>SYMPATHOMIMETICS</subject><subject>SYMPTOMS</subject><subject>TISSUES</subject><subject>TRYPTAMINES</subject><subject>VASCULAR DISEASES</subject><subject>VERTEBRATES</subject><subject>X RADIATION</subject><issn>0009-7330</issn><issn>1524-4571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><recordid>eNo9kUGP0zAQhSMEWsrCmROShVbc0rUdJ06OVVVopZVAuyBxsxxn0hicONguq_4c_inTbbU--Mkz3zxZb7LsPaNLxip2S9kyQFxW5ZIvueQvsgUruchFKdnLbEEpbXJZFPR19ibGX5QyUfDmKrvisuSloIvs325KQY-HoB3ZwuhDGPQeiJ46spk6nwZwFlvrQU97iMROZIW14KNxeCdryNoHP-lwJKuQ4CQ9CrmHGZJN9i-QzWyj73DY9-Rh1nE8ufzMgz7muxB0Z3WCjmyPMwQzeAcR51FG9P5m9_Ft9qrXLsK7i15nPz5vvq-3-d3XL7v16i43oqpFDq2gfakrCrwGg4qnEGXDRC1ZX0nddQ01XLAW6lYWwHihKZOtMYXsW9EV19nHs6-PyapobAIzGD9NYJIqK8pKUSP06QzNwf854FfVaKMB5_QE_hCVbHAr1RN4ewYNZhUD9GoOdsSYFKPqtDlFmbrfPKiqVFzh5nDiw8X60I7QPfOXVWH_5tLX0WjXBz0ZG58xWTBaswYxccYevcMg4293eISgBtAuDeopFcp4zpq6oTW-8lNJFP8BZUmzEA</recordid><startdate>198908</startdate><enddate>198908</enddate><creator>Nagasawa, Kazushige</creator><creator>Tomoike, Hitonobu</creator><creator>Hayashi, Yasuo</creator><creator>Yamada, Akira</creator><creator>Yamamoto, Torao</creator><creator>Nakamura, Motoomi</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>198908</creationdate><title>Intramural Hemorrhage and Endothelial Changes in Atherosclerotic Coronary Artery After Repetitive Episodes of Spasm in X-ray-Irradiated Hypercholesterolemic Pigs</title><author>Nagasawa, Kazushige ; Tomoike, Hitonobu ; Hayashi, Yasuo ; Yamada, Akira ; Yamamoto, Torao ; Nakamura, Motoomi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4684-eb40f5a60e28eca60000345914871f67add90c241be8b73e123a017bcc37fb4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>560152 - Radiation Effects on Animals- Animals</topic><topic>AMINES</topic><topic>Angiography</topic><topic>ANIMAL TISSUES</topic><topic>ANIMALS</topic><topic>AROMATICS</topic><topic>ARTERIES</topic><topic>ARTERIOSCLEROSIS</topic><topic>AUTONOMIC NERVOUS SYSTEM AGENTS</topic><topic>AZAARENES</topic><topic>AZOLES</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIOLOGICAL RADIATION EFFECTS</topic><topic>BLOOD VESSELS</topic><topic>BODY</topic><topic>Cardiology. Vascular system</topic><topic>CARDIOVASCULAR DISEASES</topic><topic>CARDIOVASCULAR SYSTEM</topic><topic>CHOLESTEROL</topic><topic>CORONARIES</topic><topic>Coronary Angiography</topic><topic>Coronary Artery Disease - complications</topic><topic>Coronary Artery Disease - pathology</topic><topic>Coronary Artery Disease - physiopathology</topic><topic>Coronary heart disease</topic><topic>Coronary Vasospasm - complications</topic><topic>Coronary Vessels - radiation effects</topic><topic>DISEASES</topic><topic>DOMESTIC ANIMALS</topic><topic>DRUGS</topic><topic>ELECTROMAGNETIC RADIATION</topic><topic>ELECTRON MICROSCOPY</topic><topic>ENDOTHELIUM</topic><topic>Endothelium, Vascular - pathology</topic><topic>Heart</topic><topic>Hemodynamics</topic><topic>HEMORRHAGE</topic><topic>Hemorrhage - etiology</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HYDROXY COMPOUNDS</topic><topic>Hypercholesterolemia - complications</topic><topic>INDOLES</topic><topic>IONIZING RADIATIONS</topic><topic>Male</topic><topic>MAMMALS</topic><topic>Medical sciences</topic><topic>MICROSCOPY</topic><topic>Microscopy, Electron</topic><topic>MINIATURE SWINE</topic><topic>MYOCARDIAL INFARCTION</topic><topic>NEUROREGULATORS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC NITROGEN COMPOUNDS</topic><topic>ORGANS</topic><topic>PATHOGENESIS</topic><topic>PATHOLOGICAL CHANGES</topic><topic>PERFUSED ORGANS</topic><topic>PYRROLES</topic><topic>RADIATION EFFECTS</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADIATIONS</topic><topic>RADIOPROTECTIVE SUBSTANCES</topic><topic>SEROTONIN</topic><topic>STEROIDS</topic><topic>STEROLS</topic><topic>SWINE</topic><topic>Swine, Miniature</topic><topic>SYMPATHOMIMETICS</topic><topic>SYMPTOMS</topic><topic>TISSUES</topic><topic>TRYPTAMINES</topic><topic>VASCULAR DISEASES</topic><topic>VERTEBRATES</topic><topic>X RADIATION</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nagasawa, Kazushige</creatorcontrib><creatorcontrib>Tomoike, Hitonobu</creatorcontrib><creatorcontrib>Hayashi, Yasuo</creatorcontrib><creatorcontrib>Yamada, Akira</creatorcontrib><creatorcontrib>Yamamoto, Torao</creatorcontrib><creatorcontrib>Nakamura, Motoomi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Circulation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nagasawa, Kazushige</au><au>Tomoike, Hitonobu</au><au>Hayashi, Yasuo</au><au>Yamada, Akira</au><au>Yamamoto, Torao</au><au>Nakamura, Motoomi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intramural Hemorrhage and Endothelial Changes in Atherosclerotic Coronary Artery After Repetitive Episodes of Spasm in X-ray-Irradiated Hypercholesterolemic Pigs</atitle><jtitle>Circulation research</jtitle><addtitle>Circ Res</addtitle><date>1989-08</date><risdate>1989</risdate><volume>65</volume><issue>2</issue><spage>272</spage><epage>282</epage><pages>272-282</pages><issn>0009-7330</issn><eissn>1524-4571</eissn><coden>CIRUAL</coden><abstract>To assess whether coronary spasm affects the progression of atherosclerosis and results in evolution of myocardial infarction, the role of coronary spasm on the fine structure of conduit coronary arteries was studied morphologically. Göttingen miniature pigs were fed a semisynthetic diet containing 2% cholesterol and 1.1% sodium cholate. One month after being on this diet, the pigs were anesthetized and the endothelium of a branch of the left coronary artery was denuded using a balloon catheter. X-ray irradiation in a dose of 1,500 rad was given twice selectively to the area denuded, after 4 and 5 months of cholesterol feeding. Five months after endothelial denudation, transient (group A) and repetitive episodes (group B) of coronary spasm were provoked by single and periodic (five times every 5 minutes) intracoronary injections of serotonin (10 μg/kg/injection), respectively. The extent of spasm by serotonin at the previously denuded site was 84±4% (n=4) and 90±5% (n=6) narrowing in groups A and B (p=NS between groups), respectively. Forty minutes after the final administration of serotonin, the left coronary artery was relaxed by nitroglycerin, and the heart was isolated and perfuse-fixed under physiological pressure. Intramural hemorrhage was noted at the spastic site in six pigs of group B but not in group A. The average percent luminal narrowing, on cross sections at the spastic site in group B, was significantly greater than in group A (56±7% vs. 23±5%,p<0.01). Scanning electron micrographs revealed that the endothelial lining was intact at the nonspastic site in both groups. In addition to the appearance of intercellular bridges at the spastic site in both groups, squeezing of endothelial cells and adhesion of white blood cells were present at the spastic site exclusively in group B. These findings are consistent with the hypothesis that repetitive spasm may have an important role in the progression of atherosclerosis and/or myocardial infarction. (Circulation Research 1989;65:272-282)</abstract><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>2752540</pmid><doi>10.1161/01.res.65.2.272</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-7330 |
| ispartof | Circulation research, 1989-08, Vol.65 (2), p.272-282 |
| issn | 0009-7330 1524-4571 |
| language | eng |
| recordid | cdi_osti_scitechconnect_5601548 |
| source | Freely Accessible Journals |
| subjects | 560152 - Radiation Effects on Animals- Animals AMINES Angiography ANIMAL TISSUES ANIMALS AROMATICS ARTERIES ARTERIOSCLEROSIS AUTONOMIC NERVOUS SYSTEM AGENTS AZAARENES AZOLES Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS BLOOD VESSELS BODY Cardiology. Vascular system CARDIOVASCULAR DISEASES CARDIOVASCULAR SYSTEM CHOLESTEROL CORONARIES Coronary Angiography Coronary Artery Disease - complications Coronary Artery Disease - pathology Coronary Artery Disease - physiopathology Coronary heart disease Coronary Vasospasm - complications Coronary Vessels - radiation effects DISEASES DOMESTIC ANIMALS DRUGS ELECTROMAGNETIC RADIATION ELECTRON MICROSCOPY ENDOTHELIUM Endothelium, Vascular - pathology Heart Hemodynamics HEMORRHAGE Hemorrhage - etiology HETEROCYCLIC COMPOUNDS HYDROXY COMPOUNDS Hypercholesterolemia - complications INDOLES IONIZING RADIATIONS Male MAMMALS Medical sciences MICROSCOPY Microscopy, Electron MINIATURE SWINE MYOCARDIAL INFARCTION NEUROREGULATORS ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANS PATHOGENESIS PATHOLOGICAL CHANGES PERFUSED ORGANS PYRROLES RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RADIOPROTECTIVE SUBSTANCES SEROTONIN STEROIDS STEROLS SWINE Swine, Miniature SYMPATHOMIMETICS SYMPTOMS TISSUES TRYPTAMINES VASCULAR DISEASES VERTEBRATES X RADIATION |
| title | Intramural Hemorrhage and Endothelial Changes in Atherosclerotic Coronary Artery After Repetitive Episodes of Spasm in X-ray-Irradiated Hypercholesterolemic Pigs |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T02%3A34%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_osti_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intramural%20Hemorrhage%20and%20Endothelial%20Changes%20in%20Atherosclerotic%20Coronary%20Artery%20After%20Repetitive%20Episodes%20of%20Spasm%20in%20X-ray-Irradiated%20Hypercholesterolemic%20Pigs&rft.jtitle=Circulation%20research&rft.au=Nagasawa,%20Kazushige&rft.date=1989-08&rft.volume=65&rft.issue=2&rft.spage=272&rft.epage=282&rft.pages=272-282&rft.issn=0009-7330&rft.eissn=1524-4571&rft.coden=CIRUAL&rft_id=info:doi/10.1161/01.res.65.2.272&rft_dat=%3Cproquest_osti_%3E79116648%3C/proquest_osti_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4684-eb40f5a60e28eca60000345914871f67add90c241be8b73e123a017bcc37fb4d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=79116648&rft_id=info:pmid/2752540&rfr_iscdi=true |