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A Device for Sampling of Human Alveolar Breath for the Measurement of Expired Volatile Organic Compounds
This report describes the development of a portable spirometer capable of collecting primarily alveolar breath into 1.8-L canisters for subsequent gas chromatographic/mass spectrometric (GC/MS) analysis. Based on CO2 measurements, greater than 97% of the breath collected is alveolar in origin. Sampl...
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| Published in: | Journal of analytical toxicology 1990-11, Vol.14 (6), p.337-344 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c483t-b335b8385ed0d2557046bd09696a6b87c8ac585d53451f61ee5294a49cd071303 |
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| container_end_page | 344 |
| container_issue | 6 |
| container_start_page | 337 |
| container_title | Journal of analytical toxicology |
| container_volume | 14 |
| creator | Raymer, J.H. Thomas, K.W. Cooper, S.D. Whitaker, D.A. Pellizzari, E.D. |
| description | This report describes the development of a portable spirometer capable of collecting primarily alveolar breath into 1.8-L canisters for subsequent gas chromatographic/mass spectrometric (GC/MS) analysis. Based on CO2 measurements, greater than 97% of the breath collected is alveolar in origin. Sample collection takes place in approximately two minutes. Clean air for inhalation is provided by two organic vapor respirator cartridges. Studies of the breakthrough volume of test compounds at both the 5- and 50-µg/m3 levels indicate that each cartridge filter can be used to sample over 300 L of air and that this volume is not altered by intermittent use and storage of the filter for up to five days. In experiments designed to mimic human breathing, recoveries of test compounds through the device at the 5-µg/m3 level ranged from 87 to 112%. Essentially no volatile organic compound (VOC) memory (i.e., adsorption carryover by the device) was measured at the 50-µg/m3 level. The data suggest that the device can be used successfully for organic compounds with volatilities greater than that of p-dichlorobenzene. |
| doi_str_mv | 10.1093/jat/14.6.337 |
| format | article |
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Based on CO2 measurements, greater than 97% of the breath collected is alveolar in origin. Sample collection takes place in approximately two minutes. Clean air for inhalation is provided by two organic vapor respirator cartridges. Studies of the breakthrough volume of test compounds at both the 5- and 50-µg/m3 levels indicate that each cartridge filter can be used to sample over 300 L of air and that this volume is not altered by intermittent use and storage of the filter for up to five days. In experiments designed to mimic human breathing, recoveries of test compounds through the device at the 5-µg/m3 level ranged from 87 to 112%. Essentially no volatile organic compound (VOC) memory (i.e., adsorption carryover by the device) was measured at the 50-µg/m3 level. The data suggest that the device can be used successfully for organic compounds with volatilities greater than that of p-dichlorobenzene.</description><identifier>ISSN: 0146-4760</identifier><identifier>EISSN: 1945-2403</identifier><identifier>DOI: 10.1093/jat/14.6.337</identifier><identifier>PMID: 2128356</identifier><identifier>CODEN: JATOD3</identifier><language>eng</language><publisher>Niles, IL: Oxford University Press</publisher><subject>560300 - Chemicals Metabolism & Toxicology ; ADSORBENTS ; Adsorption ; Air Pollutants - analysis ; AIR POLLUTION ; Alveoli ; ANIMALS ; Biological and medical sciences ; Breath Tests - instrumentation ; Breath Tests - methods ; Bronchospirometry - instrumentation ; Bronchospirometry - methods ; CARBON COMPOUNDS ; CARBON DIOXIDE ; Carbon Dioxide - analysis ; CARBON OXIDES ; CHALCOGENIDES ; CHARCOAL ; Chemical and industrial products toxicology. Toxic occupational diseases ; CHROMATOGRAPHY ; Data processing ; DESIGN ; Filters ; FILTRATION ; Filtration - instrumentation ; GAS CHROMATOGRAPHY ; Gas, fumes ; Humans ; Hydrocarbons - analysis ; Hydrocarbons, Chlorinated - analysis ; INHALATION ; INTAKE ; MAMMALS ; MAN ; MASS SPECTROSCOPY ; MATTER ; MEASURING INSTRUMENTS ; MEASURING METHODS ; Medical sciences ; Memory ; ORGANIC COMPOUNDS ; OXIDES ; OXYGEN COMPOUNDS ; p-Dichlorobenzene ; POLLUTION ; PORTABLE EQUIPMENT ; PRIMATES ; Pulmonary Alveoli - chemistry ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; Respiration ; Respirators ; Sampling ; SEPARATION PROCESSES ; SPECTROSCOPY ; Toxicology ; Vapors ; VERTEBRATES ; VOLATILE MATTER ; volatile organic compounds ; Volatilization</subject><ispartof>Journal of analytical toxicology, 1990-11, Vol.14 (6), p.337-344</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-b335b8385ed0d2557046bd09696a6b87c8ac585d53451f61ee5294a49cd071303</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19458416$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2128356$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5797472$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Raymer, J.H.</creatorcontrib><creatorcontrib>Thomas, K.W.</creatorcontrib><creatorcontrib>Cooper, S.D.</creatorcontrib><creatorcontrib>Whitaker, D.A.</creatorcontrib><creatorcontrib>Pellizzari, E.D.</creatorcontrib><title>A Device for Sampling of Human Alveolar Breath for the Measurement of Expired Volatile Organic Compounds</title><title>Journal of analytical toxicology</title><addtitle>Journal of Analytical Toxicology</addtitle><description>This report describes the development of a portable spirometer capable of collecting primarily alveolar breath into 1.8-L canisters for subsequent gas chromatographic/mass spectrometric (GC/MS) analysis. Based on CO2 measurements, greater than 97% of the breath collected is alveolar in origin. Sample collection takes place in approximately two minutes. Clean air for inhalation is provided by two organic vapor respirator cartridges. Studies of the breakthrough volume of test compounds at both the 5- and 50-µg/m3 levels indicate that each cartridge filter can be used to sample over 300 L of air and that this volume is not altered by intermittent use and storage of the filter for up to five days. In experiments designed to mimic human breathing, recoveries of test compounds through the device at the 5-µg/m3 level ranged from 87 to 112%. Essentially no volatile organic compound (VOC) memory (i.e., adsorption carryover by the device) was measured at the 50-µg/m3 level. The data suggest that the device can be used successfully for organic compounds with volatilities greater than that of p-dichlorobenzene.</description><subject>560300 - Chemicals Metabolism & Toxicology</subject><subject>ADSORBENTS</subject><subject>Adsorption</subject><subject>Air Pollutants - analysis</subject><subject>AIR POLLUTION</subject><subject>Alveoli</subject><subject>ANIMALS</subject><subject>Biological and medical sciences</subject><subject>Breath Tests - instrumentation</subject><subject>Breath Tests - methods</subject><subject>Bronchospirometry - instrumentation</subject><subject>Bronchospirometry - methods</subject><subject>CARBON COMPOUNDS</subject><subject>CARBON DIOXIDE</subject><subject>Carbon Dioxide - analysis</subject><subject>CARBON OXIDES</subject><subject>CHALCOGENIDES</subject><subject>CHARCOAL</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>CHROMATOGRAPHY</subject><subject>Data processing</subject><subject>DESIGN</subject><subject>Filters</subject><subject>FILTRATION</subject><subject>Filtration - instrumentation</subject><subject>GAS CHROMATOGRAPHY</subject><subject>Gas, fumes</subject><subject>Humans</subject><subject>Hydrocarbons - analysis</subject><subject>Hydrocarbons, Chlorinated - analysis</subject><subject>INHALATION</subject><subject>INTAKE</subject><subject>MAMMALS</subject><subject>MAN</subject><subject>MASS SPECTROSCOPY</subject><subject>MATTER</subject><subject>MEASURING INSTRUMENTS</subject><subject>MEASURING METHODS</subject><subject>Medical sciences</subject><subject>Memory</subject><subject>ORGANIC COMPOUNDS</subject><subject>OXIDES</subject><subject>OXYGEN COMPOUNDS</subject><subject>p-Dichlorobenzene</subject><subject>POLLUTION</subject><subject>PORTABLE EQUIPMENT</subject><subject>PRIMATES</subject><subject>Pulmonary Alveoli - chemistry</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>Respiration</subject><subject>Respirators</subject><subject>Sampling</subject><subject>SEPARATION PROCESSES</subject><subject>SPECTROSCOPY</subject><subject>Toxicology</subject><subject>Vapors</subject><subject>VERTEBRATES</subject><subject>VOLATILE MATTER</subject><subject>volatile organic compounds</subject><subject>Volatilization</subject><issn>0146-4760</issn><issn>1945-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><recordid>eNp90c1v0zAYBnALgUY3uHFFspCYOJDOjr-SYymDIhUmsYEQF8t13qweSRxsZxr_Pe5ajRvy4T08Pz0HPwi9oGROSc3Obkw6o3wu54ypR2hGay6KkhP2GM0I5bLgSpKn6DjGG0KorCQ7QkclLSsm5AxtF_g93DoLuPUBX5p-7NxwjX2LV1NvBrzobsF3JuB3AUza3qu0BfwZTJwC9DCkHT6_G12ABn_PNrkO8EW4NoOzeOn70U9DE5-hJ63pIjw_3BP07cP51XJVrC8-flou1oXlFUvFhjGxqVgloCFNKYQiXG4aUstaGrmplK2MFZVoBOOCtpICiLLmhte2IYoywk7Qq32vj8npaF0Cu7V-GMAmLVStuCozOt2jMfjfE8SkexctdJ0ZwE9RU1my_HZtb_4P8wA8_ynd0bd7aoOPMUCrx-B6E_5kdO90HkpTrqXOQ2X-8tA8bXpoHvBhmZy_PuQmWtO1wQzWxX-deeWK050r9s7FBHcPuQm_tFRMCb368VOvvqr1l8urUi_ZX42ZqHg</recordid><startdate>19901101</startdate><enddate>19901101</enddate><creator>Raymer, J.H.</creator><creator>Thomas, K.W.</creator><creator>Cooper, S.D.</creator><creator>Whitaker, D.A.</creator><creator>Pellizzari, E.D.</creator><general>Oxford University Press</general><general>Preston</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>OTOTI</scope></search><sort><creationdate>19901101</creationdate><title>A Device for Sampling of Human Alveolar Breath for the Measurement of Expired Volatile Organic Compounds</title><author>Raymer, J.H. ; Thomas, K.W. ; Cooper, S.D. ; Whitaker, D.A. ; Pellizzari, E.D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-b335b8385ed0d2557046bd09696a6b87c8ac585d53451f61ee5294a49cd071303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>560300 - Chemicals Metabolism & Toxicology</topic><topic>ADSORBENTS</topic><topic>Adsorption</topic><topic>Air Pollutants - analysis</topic><topic>AIR POLLUTION</topic><topic>Alveoli</topic><topic>ANIMALS</topic><topic>Biological and medical sciences</topic><topic>Breath Tests - instrumentation</topic><topic>Breath Tests - methods</topic><topic>Bronchospirometry - instrumentation</topic><topic>Bronchospirometry - methods</topic><topic>CARBON COMPOUNDS</topic><topic>CARBON DIOXIDE</topic><topic>Carbon Dioxide - analysis</topic><topic>CARBON OXIDES</topic><topic>CHALCOGENIDES</topic><topic>CHARCOAL</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>CHROMATOGRAPHY</topic><topic>Data processing</topic><topic>DESIGN</topic><topic>Filters</topic><topic>FILTRATION</topic><topic>Filtration - instrumentation</topic><topic>GAS CHROMATOGRAPHY</topic><topic>Gas, fumes</topic><topic>Humans</topic><topic>Hydrocarbons - analysis</topic><topic>Hydrocarbons, Chlorinated - analysis</topic><topic>INHALATION</topic><topic>INTAKE</topic><topic>MAMMALS</topic><topic>MAN</topic><topic>MASS SPECTROSCOPY</topic><topic>MATTER</topic><topic>MEASURING INSTRUMENTS</topic><topic>MEASURING METHODS</topic><topic>Medical sciences</topic><topic>Memory</topic><topic>ORGANIC COMPOUNDS</topic><topic>OXIDES</topic><topic>OXYGEN COMPOUNDS</topic><topic>p-Dichlorobenzene</topic><topic>POLLUTION</topic><topic>PORTABLE EQUIPMENT</topic><topic>PRIMATES</topic><topic>Pulmonary Alveoli - chemistry</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>Respiration</topic><topic>Respirators</topic><topic>Sampling</topic><topic>SEPARATION PROCESSES</topic><topic>SPECTROSCOPY</topic><topic>Toxicology</topic><topic>Vapors</topic><topic>VERTEBRATES</topic><topic>VOLATILE MATTER</topic><topic>volatile organic compounds</topic><topic>Volatilization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raymer, J.H.</creatorcontrib><creatorcontrib>Thomas, K.W.</creatorcontrib><creatorcontrib>Cooper, S.D.</creatorcontrib><creatorcontrib>Whitaker, D.A.</creatorcontrib><creatorcontrib>Pellizzari, E.D.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>OSTI.GOV</collection><jtitle>Journal of analytical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raymer, J.H.</au><au>Thomas, K.W.</au><au>Cooper, S.D.</au><au>Whitaker, D.A.</au><au>Pellizzari, E.D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Device for Sampling of Human Alveolar Breath for the Measurement of Expired Volatile Organic Compounds</atitle><jtitle>Journal of analytical toxicology</jtitle><addtitle>Journal of Analytical Toxicology</addtitle><date>1990-11-01</date><risdate>1990</risdate><volume>14</volume><issue>6</issue><spage>337</spage><epage>344</epage><pages>337-344</pages><issn>0146-4760</issn><eissn>1945-2403</eissn><coden>JATOD3</coden><abstract>This report describes the development of a portable spirometer capable of collecting primarily alveolar breath into 1.8-L canisters for subsequent gas chromatographic/mass spectrometric (GC/MS) analysis. Based on CO2 measurements, greater than 97% of the breath collected is alveolar in origin. Sample collection takes place in approximately two minutes. Clean air for inhalation is provided by two organic vapor respirator cartridges. Studies of the breakthrough volume of test compounds at both the 5- and 50-µg/m3 levels indicate that each cartridge filter can be used to sample over 300 L of air and that this volume is not altered by intermittent use and storage of the filter for up to five days. In experiments designed to mimic human breathing, recoveries of test compounds through the device at the 5-µg/m3 level ranged from 87 to 112%. Essentially no volatile organic compound (VOC) memory (i.e., adsorption carryover by the device) was measured at the 50-µg/m3 level. The data suggest that the device can be used successfully for organic compounds with volatilities greater than that of p-dichlorobenzene.</abstract><cop>Niles, IL</cop><pub>Oxford University Press</pub><pmid>2128356</pmid><doi>10.1093/jat/14.6.337</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0146-4760 |
| ispartof | Journal of analytical toxicology, 1990-11, Vol.14 (6), p.337-344 |
| issn | 0146-4760 1945-2403 |
| language | eng |
| recordid | cdi_osti_scitechconnect_5797472 |
| source | Alma/SFX Local Collection |
| subjects | 560300 - Chemicals Metabolism & Toxicology ADSORBENTS Adsorption Air Pollutants - analysis AIR POLLUTION Alveoli ANIMALS Biological and medical sciences Breath Tests - instrumentation Breath Tests - methods Bronchospirometry - instrumentation Bronchospirometry - methods CARBON COMPOUNDS CARBON DIOXIDE Carbon Dioxide - analysis CARBON OXIDES CHALCOGENIDES CHARCOAL Chemical and industrial products toxicology. Toxic occupational diseases CHROMATOGRAPHY Data processing DESIGN Filters FILTRATION Filtration - instrumentation GAS CHROMATOGRAPHY Gas, fumes Humans Hydrocarbons - analysis Hydrocarbons, Chlorinated - analysis INHALATION INTAKE MAMMALS MAN MASS SPECTROSCOPY MATTER MEASURING INSTRUMENTS MEASURING METHODS Medical sciences Memory ORGANIC COMPOUNDS OXIDES OXYGEN COMPOUNDS p-Dichlorobenzene POLLUTION PORTABLE EQUIPMENT PRIMATES Pulmonary Alveoli - chemistry RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT Respiration Respirators Sampling SEPARATION PROCESSES SPECTROSCOPY Toxicology Vapors VERTEBRATES VOLATILE MATTER volatile organic compounds Volatilization |
| title | A Device for Sampling of Human Alveolar Breath for the Measurement of Expired Volatile Organic Compounds |
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