Free magnesium levels in normal human brain and brain tumors: sup 31 P chemical-shift imaging measurements at 1. 5 T

The authors have studied a series of normal subjects and patients with brain tumors, by using {sup 31}P three-dimensional chemical shift imaging to obtain localized {sup 31}P spectra of the brain. A significant proportion of brain cytosolic ATP in normal brain is not complexed to Mg{sup 2+}, as indi...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1991-08, Vol.88:15
Main Authors: Taylor, J.S., Vigneron, D.B., Murphy-Boesch, J., Nelson, S.J., Kessler, H.B., Coia, L., Curran, W., Brown, T.R.
Format: Article
Language:English
Subjects:
550601 - Medicine- Unsealed Radionuclides in Diagnostics
ABSORPTION SPECTRA
ALKALINE EARTH METAL COMPOUNDS
AMINO ACIDS
ANIMALS
BODY
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHEMICAL SHIFT
COENZYMES
CREATINE
DIAGNOSIS
DISEASES
ISOTOPES
LIGHT NUCLEI
MAGNESIUM COMPOUNDS
MAMMALS
MAN
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PHOSPHORUS 31
PHOSPHORUS ISOTOPES
PRIMATES
RADIOLOGY AND NUCLEAR MEDICINE
SPECTRA
SPECTROSCOPY
STABLE ISOTOPES
VERTEBRATES
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Summary:The authors have studied a series of normal subjects and patients with brain tumors, by using {sup 31}P three-dimensional chemical shift imaging to obtain localized {sup 31}P spectra of the brain. A significant proportion of brain cytosolic ATP in normal brain is not complexed to Mg{sup 2+}, as indicated by the chemical shift {delta} of the {beta}-P resonance of ATP. The ATP {beta}P resonance position in brain thus is sensitive to changes in intracellular free Mg{sup 2+} concentration and in the proportion of ATP complexed with Mg because this shift lies on the rising portion of the {delta} vs. Mg{sup 2+} titration curve for ATP. They have measured the ATP {beta}-P shift and compared intracellular free Mg{sup 2+} concentration and fractions of free ATP for normal individuals and a limited series of patients with brain tumors. In four of the five spectra obtained from brain tissue containing a substantial proportion of tumor, intracellular free Mg{sup 2+} was increased, and the fraction of free ATP was decreased, compared with normal brain.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.88.15.6810