Radioprotection of Mice by a Single Subcutaneous Injection of Heat-Killed Lactobacillus casei after Irradiation

Treatment of whole-body γ-irradiated mice with a preparation of Lactobacillus casei (LC 9018) immediately after irradiation caused a sustained increase in serum colony-stimulating activity which was followed by an enhanced repopulation of granulocyte-macrophage colony-forming cells in the femoral ma...

Full description

Saved in:
Bibliographic Details
Published in:Radiation research 1991-03, Vol.125 (3), p.293-297
Main Authors: Nomoto, Koji, Yokokura, Teruo, Tsuneoka, Kazuko, Shikita, Mikio
Format: Article
Language:English
Subjects:
560152 - Radiation Effects on Animals- Animals
Adjuvants, Immunologic - administration & dosage
Adjuvants, Immunologic - therapeutic use
ANIMALS
BACTERIA
Biological and medical sciences
Blood Cell Count - drug effects
COLONY FORMATION
Colony stimulating factors
Colony-Forming Units Assay
Dose-Response Relationship, Drug
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
Erythrocytes
EXTERNAL IRRADIATION
GAMMA RADIATION
Injections, Subcutaneous
IONIZING RADIATIONS
IRRADIATION
LACTOBACILLUS
Lactobacillus casei
Leukocytes
Male
MAMMALS
Medical sciences
MICE
Mice, Inbred C3H
MICROORGANISMS
Platelets
Radiation dosage
Radiation Injuries, Experimental - prevention & control
RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT
Radiation-Protective Agents - administration & dosage
Radiation-Protective Agents - therapeutic use
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
Radiotherapy
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
RODENTS
Spleen
Subcutaneous injections
VERTEBRATES
WHOLE-BODY IRRADIATION
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Treatment of whole-body γ-irradiated mice with a preparation of Lactobacillus casei (LC 9018) immediately after irradiation caused a sustained increase in serum colony-stimulating activity which was followed by an enhanced repopulation of granulocyte-macrophage colony-forming cells in the femoral marrow and spleen. Numbers of blood leukocytes, erythrocytes, and platelets were increased earlier in the treated mice than in the controls, and the survival rate was elevated significantly. The radioprotective effect was dependent on the dose of LC 9018 as well as on the dose of radiation. These results demonstrate the value of LC 9018 for the treatment of myelosuppression after radiotherapy or radiation accidents.
ISSN:0033-7587
1938-5404
DOI:10.2307/3578113