Diagnostic value of a new myocardial perfusion agent, teboroxime (SQ 30,217), utilizing a rapid planar imaging protocol: Preliminary results

• Published in: Journal of the American College of Cardiology 1990-10, Vol.16 (4), p.855-861
• Main Authors: Hendel, Robert C., McSherry, Brenda, Karimeddini, Mozafareddin, Leppo, Jeffrey A.
• Format: Article
• Language: English
• Subjects: 550601 - Medicine- Unsealed Radionuclides in Diagnostics; Adult; Aged; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; Biological and medical sciences; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; COMPARATIVE EVALUATIONS; Contrast media. Radiopharmaceuticals; Coronary Angiography; Coronary Disease - diagnosis; Coronary Vessels - diagnostic imaging; DAYS LIVING RADIOISOTOPES; DIAGNOSIS; Diagnostic Imaging - methods; DISEASES; DRUGS; EFFICIENCY; ELECTRON CAPTURE RADIOISOTOPES; EXERCISE; Exercise Test; Female; HEART; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; Humans; IMAGE PROCESSING; INTERMEDIATE MASS NUCLEI; ISOMERIC NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; Male; Medical sciences; Middle Aged; MUSCLES; MYOCARDIUM; NUCLEI; ODD-EVEN NUCLEI; Organotechnetium Compounds; ORGANS; Oximes; Pharmacology. Drug treatments; PROCESSING; RADIOISOTOPES; RADIOLOGY AND NUCLEAR MEDICINE; Radionuclide Imaging; RADIOPHARMACEUTICALS; SECONDS LIVING RADIOISOTOPES; TECHNETIUM 99; TECHNETIUM ISOTOPES; THALLIUM 201; THALLIUM ISOTOPES; Thallium Radioisotopes; YEARS LIVING RADIOISOTOPES
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/S0735-1097(10)80333-X

Technetium-99m-labeled agents have advantages over thallium-201 in terms of photon statistics, cost and clinical availability. They have been suggested as an alternative to thallium for myocardial perfusion imaging. Teboroxime is a new boronic acid adduct of technetium dioxime (BATO) compound that demonstrates favorable characteristics in preliminary studies. With use of a novel (seated) patient positioning technique and a rapid dynamic acquisition protocol, 30 patients underwent planar imaging with teboroxime while at rest and after maximal treadmill exercise. Postexercise scans were completed in an average time (mean ± SD) of 4.4 ± 1.6 min, with 4.8 ± l.S min for the views at rest. These results were compared with coronary arteriography or thallium scintigraphy after treadmill exercise, or both. Diagnostic agreement (abnormal versus normal) was present in 28 of the 30 patients (p < 0.001). Regarding physiologic assessment as compared with thallium scintigraphy, the finding of infarction and ischemia was concordant in 89% and 86% of patients, respectively. This report describes the initial use of teboroxime with a rapid dynamic planar imaging technique, resulting in a high correlation with exercise thallium scintigraphy. Delayed postexercise images obtained 5 to 10 min after exercise demonstrated rapid disappearance of exercise-induced defects noted on the initial (0 to 5 min) postexercise views. The rapid differential washout with teboroxime has not been previously described and the possible clinical significance is discussed.