The Adipose Tissue to Serum Dichlorodiphenyldichloroethane (DDE) Ratio: Some Methodological Considerations

Dichlorodiphenyldichloroethane (DDE) adipose tissue level has been regarded as a preferred indicator of accumulated human exposure to DDT; however, blood sera are more feasible to obtain and analyze than adipose tissue samples. Inconsistent and scarce information exists in relation to the adipose ti...

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Bibliographic Details
Published in:Environmental research 1999-08, Vol.81 (2), p.142-145
Main Authors: López-Carrillo, Lizbeth, Torres-Sánchez, Luisa, López-Cervantes, Malaquı́as, Blair, Aaron, Cebrián, Mariano E., Uribe, Marisela
Format: Article
Language:English
Subjects:
560300 - Chemicals Metabolism & Toxicology
ADIPOSE TISSUE
Adipose Tissue - metabolism
Adult
Aged
ANIMAL TISSUES
BIOLOGICAL ACCUMULATION
Biological and medical sciences
BLOOD SERUM
BODY
BODY BURDEN
CONNECTIVE TISSUE
DDT
Dichlorodiphenyl Dichloroethylene - pharmacokinetics
Female
Humans
Insecticides - pharmacokinetics
Medical sciences
Middle Aged
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
organochlorine compounds
Pesticides, fertilizers and other agrochemicals toxicology
RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT
reproductive characteristics
Toxicology
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Summary:Dichlorodiphenyldichloroethane (DDE) adipose tissue level has been regarded as a preferred indicator of accumulated human exposure to DDT; however, blood sera are more feasible to obtain and analyze than adipose tissue samples. Inconsistent and scarce information exists in relation to the adipose tissue/serum DDE ratio. As a part of a hospital-based case–control study performed in Mexico City from 1994 to 1996, 198 paired serum and adipose tissue samples were obtained from 72 women with histologically confirmed breast cancer and 126 women with benign breast disease. Both adipose tissue and serum DDE levels were determined by gas–liquid chromatography and reported as ppb lipid weight (ng/g) as well as wet basis (ng/ml). Results showed that the adipose tissue/serum DDE ratio (ADSE) varies according to the type of information (lipid vs wet basis, arithmetic vs geometric means) used for its estimation. ADSE gets a value near 1 (1.1) only when the geometric DDE levels in lipid basis are used for its estimation. The correlation between DDE serum and adipose tissue levels was found (r=0.364, P
ISSN:0013-9351
1096-0953
DOI:10.1006/enrs.1999.3961