Influence of maternal ingestion of aroclor 1254® (PCB) or firemaster BP-6® (PBB) on unstimulated and stimulated corticosterone levels in young rats

Since early studies showed that hypothyroidism induced by feeding pregnant rats the goitrogen thiouracil altered the functional capabilities in their young of the hypothalamus-pituitary-adrenal (HPA) axis, as revealed by circulating corticosterone levels, the present study was done to determine whet...

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Bibliographic Details
Published in:Bulletin of environmental contamination and toxicology 1992-05, Vol.48 (5), p.715-720
Main Authors: MESERVE, L. A, MURRAY, B. A, LANDIS, J. A
Format: Article
Language:English
Subjects:
ADRENAL HORMONES
ANIMALS
Aroclors - toxicity
AROMATICS
Biological and medical sciences
BIOLOGICAL EFFECTS
Body Weight - drug effects
CHLORINATED AROMATIC HYDROCARBONS
Chlorodiphenyl (54% Chlorine)
CORTICOSTEROIDS
CORTICOSTERONE
Corticosterone - blood
Dose-Response Relationship, Drug
ECOLOGICAL CONCENTRATION
Environmental pollutants toxicology
Female
General aspects
GLUCOCORTICOIDS
HALOGENATED AROMATIC HYDROCARBONS
HORMONES
HYDROXY COMPOUNDS
Hypothalamo-Hypophyseal System - drug effects
Hypothalamo-Hypophyseal System - physiology
JUVENILES
KETONES
LACTATION
Lactation - drug effects
Lactation - physiology
Liver - anatomy & histology
Male
MAMMALS
Medical sciences
Organ Size - drug effects
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
Pituitary-Adrenal System - drug effects
Pituitary-Adrenal System - physiology
Polybrominated Biphenyls - toxicity
POLYCHLORINATED BIPHENYLS
PREGNANCY
Pregnancy, Animal - blood
Pregnancy, Animal - drug effects
Pregnancy, Animal - physiology
PREGNANES
Prenatal Exposure Delayed Effects
RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT
RATS
Rats, Inbred Strains
RODENTS
STEROID HORMONES
STEROIDS
Thyroid Gland - drug effects
Thyroid Gland - physiology
Toxicology
VERTEBRATES 560300 > Chemicals Metabolism & Toxicology
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Summary:Since early studies showed that hypothyroidism induced by feeding pregnant rats the goitrogen thiouracil altered the functional capabilities in their young of the hypothalamus-pituitary-adrenal (HPA) axis, as revealed by circulating corticosterone levels, the present study was done to determine whether ingestion of either PCB (Aroclor 1254) or PBB (FireMaster BP-6) by pregnant and lactating rats resulted in depressed thyroid status and/or modified HPA axis function in their 15 day old young.
ISSN:0007-4861
1432-0800
DOI:10.1007/BF00195992